典型文献
Role of Akkermansia muciniphila in the development of nonalcoholic fatty liver disease:current knowledge and perspectives
文献摘要：
Nonalcoholic fatty liver disease(NAFLD)is a hepatic manifestation of metabolic syndrome and a common cause of liver cirrhosis and cancer.Akkermansia muciniphila(A.muciniphila)is a next-generation probiotic that has been reported to improve metabolic disorders.Emerging evidence indicates the therapeutic potential of A.muciniphila for NAFLD,especially in the inflammatory stage,nonalcoholic steatohepatitis.Here,the current knowledge on the role of A.muciniphila in the progression of NAFLD was summarized.A.muciniphila abundancy is decreased in animals and humans with NAFLD.The recovery of A.muciniphila presented benefits in preventing hepatic fat accumulation and inflammation in NAFLD.The details of how microbes regulate hepatic immunity and lipid accumulation in NAFLD were further discussed.The modulation mechanisms by which A.muciniphila acts to improve hepatic inflammation are mainly attributed to the alleviation of inflammatory cytokines and LPS signals and the downregulation of microbiota-related innate immune cells(such as macrophages).This review provides insights into the roles of A.muciniphila in NAFLD,thereby providing a blueprint to facilitate clinical therapeutic applications.
文献关键词：
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作者姓名：
Yuqiu Han;Lanjuan Li;Baohong Wang
作者机构：
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,National Clinical Research Center for Infectious Diseases,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China;Research Units of Infectious disease and Microecology,Chinese Academy of Medical Sciences,Hangzhou 310003,China;Jinan Microecological Biomedicine Shandong Laboratory,Jinan 250117,China
文献出处：
引用格式：
[1]Yuqiu Han;Lanjuan Li;Baohong Wang-.Role of Akkermansia muciniphila in the development of nonalcoholic fatty liver disease:current knowledge and perspectives)[J].医学前沿,2022(05):667-685
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0.611607
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