典型文献
Fighting type 2 diabetes:Formulation strategies for peptide-based therapeutics
文献摘要：
Diabetes mellitus is a major health problem with increasing prevalence at a global level.The discovery of insulin in the early 1900s represented a major breakthrough in diabetes management,with further milestones being subsequently achieved with the identification of glucagon-like peptide-1(GLP-1)and the introduction of GLP-1 receptor agonists(GLP-1 RAs)in clinical practice.Moreover,the subcu-taneous delivery of biotherapeutics is a well-established route of administration generally preferred over the intravenous route due to better patient compliance and prolonged drug absorption.However,current subcu-taneous formulations of GLP-1 RAs present pharmacokinetic problems that lead to adverse reactions and treatment discontinuation.In this review,we discuss the current challenges of subcutaneous administration of peptide-based therapeutics and provide an overview of the formulations available for the different routes of administration with improved bioavailability and reduced frequency of administration.
文献关键词：
中图分类号：
作者姓名：
Carlos Bendicho-Lavilla;Iria Seoane-Via?o;Francisco J.Otero-Espinar;Asteria Luzardo-álvarez
作者机构：
Department of Pharmacology,Pharmacy and Pharmaceutical Technology,Faculty of Pharmacy,University of Santiago de Compostela(USC),Santiago de Compostela 15782,Spain;Paraquasil Group,Health Research Institute of Santiago de Compostela(IDIS),Santiago de Compostela 15706,Spain;Department of Pharmacology,Pharmacy and Pharmaceutical Technology,School of Sciences,Campus de Lugo,University of Santiago de Compostela,Lugo 27002,Spain
文献出处：
引用格式：
[1]Carlos Bendicho-Lavilla;Iria Seoane-Via?o;Francisco J.Otero-Espinar;Asteria Luzardo-álvarez-.Fighting type 2 diabetes:Formulation strategies for peptide-based therapeutics)[J].药学学报（英文版）,2022(02):621-636
A类：
subcu,biotherapeutics
B类：
Fighting,type,diabetes,Formulation,strategies,peptide,Diabetes,mellitus,major,health,increasing,prevalence,global,level,discovery,insulin,early,1900s,represented,breakthrough,management,further,milestones,being,subsequently,achieved,identification,glucagon,like,GLP,introduction,receptor,agonists,RAs,clinical,practice,Moreover,delivery,well,established,administration,generally,preferred,intravenous,due,better,patient,compliance,prolonged,drug,absorption,However,current,formulations,pharmacokinetic,problems,that,lead,adverse,reactions,treatment,discontinuation,In,this,review,discuss,challenges,subcutaneous,provide,overview,available,different,routes,improved,bioavailability,reduced,frequency
AB值：
0.609565
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