典型文献
Screening for a 177Lu-labeled CA19-9 monoclonal antibody via PET imaging for colorectal cancer therapy
文献摘要：
Carbohydrate antigen 19-9(CA19-9)with multi epitopes relatively high expresses on colorectal cancer(CRC)cells,making it an attractive target for developing radioimmunotherapy(RIT)for CRC.The lutetium-177(177Lu)labeled monoclonal antibodies(mAbs)can selectively bind the corresponding antigens and release targeted cytotoxic radiation,which could induce cell apoptosis and reduce the drug-induced re-sistance.Here,a series of CA19-9 mAbs were labeled with zirconium-89(89Zr),and one with high tumor uptake was screened via PET imaging,which has potential application for the diagnosis of CRC.Then the screened mAb(C003)labeled with 177Lu was utilized for CA19-9 targeted RIT,which presents a signifi-cant suppression effect on the growth of colo205 xenografts than immunotherapy alone.Meanwhile,the side effects of 177Lu-DOTA-C003 are limited according to the results of in vivo study.Both 89Zr-DFO-C003 for CRC immune-PET imaging and 177Lu-DOTA-C003 for RIT against CRC exhibit good potential in clinical applications.
文献关键词：
中图分类号：
作者姓名：
Jing Wang;Liangang Zhuo;Peng Zhao;Wei Liao;Hongyuan Wei;Yuchuan Yang;Shuming Peng;Xia Yang
作者机构：
Institute of Nuclear Physics and Chemistry,China Academy of Engineering Physics,Mianyang 621900,China;NHC Key Laboratory of Nuclear Technology Mediccal Trasnformation(Mianyang Central Hospital),Mianyang 621900,China;Key Laboratory of Nuclear Medicine and Molecular Imaging of Sichuan Province,Mianyang 621999,China;Department of Nuclear Medicine,The Affiliated Hospital Southwest of Medical University,Luzhou 646000,China
文献出处：
引用格式：
[1]Jing Wang;Liangang Zhuo;Peng Zhao;Wei Liao;Hongyuan Wei;Yuchuan Yang;Shuming Peng;Xia Yang-.Screening for a 177Lu-labeled CA19-9 monoclonal antibody via PET imaging for colorectal cancer therapy)[J].中国化学快报（英文版）,2022(07):3502-3506
A类：
radioimmunotherapy,C003,colo205
B类：
Screening,177Lu,labeled,CA19,monoclonal,antibody,via,PET,imaging,colorectal,cancer,Carbohydrate,multi,epitopes,relatively,high,expresses,CRC,cells,making,attractive,developing,RIT,lutetium,antibodies,mAbs,selectively,bind,corresponding,antigens,release,targeted,cytotoxic,radiation,which,could,apoptosis,reduce,drug,induced,sistance,Here,series,were,zirconium,89Zr,tumor,uptake,was,screened,has,potential,diagnosis,Then,utilized,presents,signifi,cant,suppression,growth,xenografts,than,alone,Meanwhile,side,effects,DOTA,are,limited,according,results,vivo,study,Both,DFO,immune,against,exhibit,good,clinical,applications
AB值：
0.520304
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