典型文献
Metformin booster adipocyte-targeted gene therapy for the treatment of obesity and related metabolic syndromes
文献摘要：
Obesity has become an important public problem that endangers human conditions and urgently needs to be solved.However,most weight-loss drugs on the market have little effect and are accompanied by adverse effects such as strokes and heart attacks.Here,we construct an adipocyte-targeting polypeptide-based gene carrier consisting of an adipocyte-targeting peptide and p-toluylsulfonyl arginine-modified polylysine(ATS-PLL-RT),which can specifically bind to the prohibitin of mature adipocytes.We further construct a short hairpin RNA(shRNA)to simultaneously silence fatty acid binding proteins 4 and 5(shFABP4/5).FABPs are molecular chaperones for fatty acid metabolism and storage in cells.Moreover,we introduce metformin for combined therapy.First,the metformin combination can effectively improve the efficiency of gene transfection.In addition,metformin itself has an alleviating effect on diet-induced obesity and relevant metabolic diseases.The combination treatment of obese mice with ATS-PLL-RT/shFABP4/5 and metformin achieves body weight reduction and metabolic recovery.This study provides a potentially effective strategy for the clinical treatment of obesity as well as mitigating obesity-induced metabolic syndromes.
文献关键词：
中图分类号：
作者姓名：
Jie Chen;Jee Young Chung;Huapan Fang;Lin Lin;Yong-Hee Kim;Huayu Tian;Xuesi Chen
作者机构：
Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China;Department of Bioengineering,Institute for Bioengineering and Biopharmaceutical Research,BK 21 Plus Future Biopharmaceutical Human Resources Training and Research Team,Hanyang University,133-791 Seoul,Republic of Korea
文献出处：
引用格式：
[1]Jie Chen;Jee Young Chung;Huapan Fang;Lin Lin;Yong-Hee Kim;Huayu Tian;Xuesi Chen-.Metformin booster adipocyte-targeted gene therapy for the treatment of obesity and related metabolic syndromes)[J].中国科学:化学（英文版）,2022(04):796-809
A类：
toluylsulfonyl,shFABP4
B类：
Metformin,booster,targeted,gene,therapy,treatment,obesity,related,metabolic,syndromes,Obesity,has,become,important,public,problem,that,endangers,human,conditions,urgently,needs,solved,However,most,weight,loss,drugs,market,have,little,are,accompanied,by,adverse,effects,such,strokes,heart,attacks,Here,construct,targeting,polypeptide,carrier,consisting,arginine,modified,polylysine,ATS,PLL,which,can,specifically,prohibitin,mature,adipocytes,We,further,short,hairpin,shRNA,simultaneously,silence,fatty,acid,binding,proteins,FABPs,molecular,chaperones,metabolism,storage,cells,Moreover,introduce,metformin,combined,First,combination,effectively,improve,efficiency,transfection,In,addition,itself,alleviating,diet,induced,relevant,diseases,obese,mice,achieves,body,reduction,recovery,This,study,provides,potentially,strategy,clinical,well,mitigating
AB值：
0.616207
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
