典型文献
Integrating of lipophilic platinum(Ⅳ)prodrug into liposomes for cancer therapy on patient-derived xenograft model
文献摘要：
Platinum-based anticancer agents such as cisplatin and its analogues are widely used for treating multi-ple cancers.However,due to the inferior water-solubility,chemoresistance and consequent adverse side effects,their clinical applications are limited.Herein,cholesPt(Ⅳ),a lipophilic platinum(Ⅳ)prodrug was synthesized for manufacture of CholesPt(Ⅳ)-Liposomes aiming to resolve the predefined obstacles en-countered by platinum drugs.Following systematic screening,CholesPt(Ⅳ)-Liposomes showed a small particle size(105.6 nm),the rapid release of platinum(Pt)ions,and notable apoptosis of cancer cells.In addition,according to the fluidity and safety results of animal experiments in mice,CholesPt(Ⅳ)-Liposomes also showed better therapeutic effect,which significantly inhibited the growth of patient-derived xenograft tumors of hepatocellular carcinoma with an inhibition ratio of 80.7％,and effectively alleviated the drug toxicity brought by traditional platinum drugs.Overall,this study provides a promis-ing route to enhance the therapeutic efficiency of platinum drugs in cancer treatment.
文献关键词：
中图分类号：
作者姓名：
Zibo Li;Qing Xu;Xuefeng Lin;Kunyi Yu;Ling Lin;Yangjia Liu;Zhiqiang Yu;Tiancai Liu;Dixian Luo
作者机构：
Department of Laboratory Medicine,Huazhong University of Science and Technology Union Shenzhen Hospital(Nanshan Hospital),Shenzhen 518000,China;Guangdong Provincial Key Laboratory of New Drug Screening,School of Pharmaceutical Sciences,Southern Medical University,Guangzhou 510515,China;School of Laboratory Medicine and Biotechnology,Institute of Antibody Engineering,Southern Medical University,Guangzhou 510515,China
文献出处：
引用格式：
[1]Zibo Li;Qing Xu;Xuefeng Lin;Kunyi Yu;Ling Lin;Yangjia Liu;Zhiqiang Yu;Tiancai Liu;Dixian Luo-.Integrating of lipophilic platinum(Ⅳ)prodrug into liposomes for cancer therapy on patient-derived xenograft model)[J].中国化学快报（英文版）,2022(04):1875-1879
A类：
cholesPt,CholesPt
B类：
Integrating,lipophilic,platinum,prodrug,into,liposomes,therapy,patient,derived,xenograft,model,Platinum,anticancer,agents,such,cisplatin,its,analogues,are,widely,used,treating,multi,ple,cancers,However,due,inferior,water,solubility,chemoresistance,consequent,adverse,side,effects,their,clinical,applications,limited,Herein,was,synthesized,manufacture,Liposomes,aiming,resolve,predefined,obstacles,countered,by,drugs,Following,systematic,screening,showed,small,particle,rapid,release,notable,apoptosis,cells,addition,according,fluidity,safety,results,animal,experiments,mice,also,better,therapeutic,which,significantly,inhibited,growth,tumors,hepatocellular,carcinoma,inhibition,ratio,effectively,alleviated,toxicity,brought,traditional,Overall,this,study,provides,promis,route,enhance,efficiency,treatment
AB值：
0.641788
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