Atrial fibrillation is an"invisible killer"of human health.It often induces high-risk diseases,such as myocardial infarction,stroke,and heart failure.Fortunately,atrial fibrillation can be diagnosed and trea-ted early.Low-level vagus nerve stimulation(LL-VNS)is a promising therapeutic method for atrial fibril-lation.However,some fundamental challenges still need to be overcome in terms of flexibility,miniaturization,and long-term service of bioelectric stimulation devices.Here,we designed a closed-loop self-powered LL-VNS system that can monitor the patient's pulse wave status in real time and con-duct stimulation impulses automatically during the development of atrial fibrillation.The implant is a hybrid nanogenerator(H-NG),which is flexible,light weight,and simple,even without electronic circuits,components,and batteries.The maximum output of the H-NG was 14.8 V and 17.8 μA(peak to peak).In the in vivo effect verification study,the atrial fibrillation duration significantly decreased by 90％after LL-VNS therapy,and myocardial fibrosis and atrial connexin levels were effectively improved.Notably,the anti-inflammatory effect triggered by mediating the NF-κB and AP-1 pathways in our therapeutic system is observed.Overall,this implantable bioelectronic device is expected to be used for self-powerability,intelligentization,portability for management,and therapy of chronic diseases.

Yu Sun;Shengyu Chao;Han Ouyang;Weiyi Zhang;Weikang Luo;Qingbin Nie;Jianing Wang;Changyi Luo;Gongang Ni;Lingyu Zhang;Jun Yang;Hongqing Feng;Gengsheng Mao;Zhou Li

Department of Neurosurgery,General Hospital of Armed Police Forces,Anhui Medical University,Hefei 230032,China;Department of Neurosurgery,The Third Medical Centre,Chinese People's Liberation Army General Hospital,Beijing 100039,China;Beijing Key Laboratory of Micro-nano Energy and Sensor,Beijing Institute of Nanoenergy and Nanosystems,Chinese Academy of Sciences,Beijing 101400,China;School of Nanoscience and Technology,University of Chinese Academy of Sciences,Beijing 100049,China;Institute of Integrative Medicine.Department of Integrated Traditional Chinese and Western Medicine,Xiangya Hospital,Central South University,Changsha 410008,China;Department of Neurosurgery,Peking University Third Hospital,Beijing 100191,China;School of Chemistry and Chemical Engineering,Center on Nanoenergy Research,Guangxi University,Nanning 530004,China;Institute for Stem Cell and Regeneration,Chinese Academy of Sciences,Beijing 100101,China

科学通报（英文版）

[1]Yu Sun;Shengyu Chao;Han Ouyang;Weiyi Zhang;Weikang Luo;Qingbin Nie;Jianing Wang;Changyi Luo;Gongang Ni;Lingyu Zhang;Jun Yang;Hongqing Feng;Gengsheng Mao;Zhou Li-.Hybrid nanogenerator based closed-loop self-powered low-level vagus nerve stimulation system for atrial fibrillation treatment)[J].科学通报（英文版）,2022(12):1284-1294

bioelectric,powerability

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