典型文献
Blood-based Alzheimer's disease diagnosis using fluorescent peptide nanoparticle arrays
文献摘要：
There is a critical need to diagnose and monitor the progression of Alzheimer's disease(AD)using blood-based biomarkers.At present,it is believed that tau biomarkers can be utilized to reliably detect AD.Multimodal techniques are highly sought after for AD diagnosis and progression monitoring.For this pur-pose,we developed a fluorescent peptide nanoparticles(f-PNPs)arrays that is capable of detecting multi-ple signals simultaneously.The concentration,aggregation stages,and Young's modulus of tau biomarkers could be analyzed by monitoring the changes of multimodal fluorescence intensity,nano-morphological,and nano-mechanical properties of the f-PNPs arrays.Experimental results indicated that,compared to healthy human,the concentration,Young's modulus,and aggregation levels of tau proteins in blood sam-ples of clinically diagnosed AD patients increased continuously with the increase of disease severity.The minimally invasive and multimodal characterization techniques showed high signal-to-noise ratio for AD diagnosis.
文献关键词：
中图分类号：
作者姓名：
Leming Sun;Yang Lei;Yuerong Wang;Dingchang Liu
作者机构：
Key Laboratory of Space Bioscience and Biotechnology,School of Life Sciences,Northwestern Polytechnical University,Xi'an 710072,China
文献出处：
引用格式：
[1]Leming Sun;Yang Lei;Yuerong Wang;Dingchang Liu-.Blood-based Alzheimer's disease diagnosis using fluorescent peptide nanoparticle arrays)[J].中国化学快报（英文版）,2022(04):1946-1950
A类：
PNPs
B类：
Blood,Alzheimer,disease,diagnosis,using,fluorescent,peptide,arrays,There,critical,need,progression,AD,blood,biomarkers,At,present,believed,that,tau,can,utilized,reliably,Multimodal,techniques,highly,sought,after,monitoring,For,this,pur,pose,developed,nanoparticles,capable,detecting,signals,simultaneously,concentration,aggregation,stages,Young,modulus,could,analyzed,by,changes,multimodal,fluorescence,intensity,morphological,mechanical,properties,Experimental,results,indicated,compared,healthy,human,levels,proteins,sam,ples,clinically,diagnosed,patients,increased,continuously,severity,minimally,invasive,characterization,showed,noise
AB值：
0.544835
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