典型文献
Microfluidics-based single cell sequencing:moving towards more physiological analysis
文献摘要：
Single cell assays provide an unprecedented resource for exploring life health and disease research,and play a fun-damental role in human protein atlas(HPA)and human genome project(HGP).Heterogeneity,the central focus of single-cell analysis,is defined with the various performances on the morphology,function,composition and gene even in a same scope of cell types.Especially after avoiding the signal loss based on the average analysis,the single-cell sequencing exhibited a great potential on clonal dynamics,the elucida-tion for different cell type composition and the mapping the gene-regulatory logic of human disease.For example,the combination of single-cell chromatin sequencing and RNA sequencing could complete a gene-regulatory atlas creation and identify a crucial genomic region for human cortico-genesis[1].Single-cell RNA analysis in fibroblasts could assist to distinguish the characterization between healthy and diseased organs at a single-cell resolution[2].Meanwhile,a breakthrough on single cell three-dimensional(3D)genome measurement could detect known genome structures,which could work as an efficient tool for studying heterogeneous populations[3].In brief,the development of a single cell sequencing platform with physiological and pathological significance is attracting more attention of the scientific re-searchers.
文献关键词：
中图分类号：
作者姓名：
Shuo Feng;Jin-Ming Lin
作者机构：
Department of Chemistry,Beijing Key Laboratory of Microanalytical Methods and Instrumentation,Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology(Ministry of Education),Tsinghua University,Beijing 100084,China
文献出处：
引用格式：
[1]Shuo Feng;Jin-Ming Lin-.Microfluidics-based single cell sequencing:moving towards more physiological analysis)[J].中国科学:化学（英文版）,2022(02):207-209
A类：
elucida
B类：
Microfluidics,single,cell,sequencing,moving,towards,more,physiological,analysis,Single,assays,provide,unprecedented,resource,exploring,life,research,play,damental,role,human,protein,atlas,HPA,genome,project,HGP,Heterogeneity,central,focus,defined,various,performances,morphology,function,composition,even,same,scope,types,Especially,after,avoiding,signal,loss,average,exhibited,great,potential,clonal,dynamics,different,mapping,regulatory,For,example,combination,chromatin,could,complete,creation,identify,crucial,genomic,region,cortico,genesis,fibroblasts,assist,distinguish,characterization,between,healthy,diseased,organs,resolution,Meanwhile,breakthrough,three,dimensional,measurement,detect,known,structures,which,work,efficient,tool,studying,heterogeneous,populations,In,brief,development,platform,pathological,significance,attracting,attention,scientific,searchers
AB值：
0.606955
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