典型文献
Profiling biotoxicities of hexafluoropropylene oxide trimer acid with human embryonic stem cell-based assays
文献摘要：
Hexafluoropropylene oxide trimer acid(HFPO-TA),an emerging replacement of perfluorooc-tanoic acid(PFOA),has recently been reported to be a potential environmental contaminant.Due to the similar structure to PFOA,HFPO-TA may cause comparable adverse effects on hu-man health.Therefore,evaluating the toxic profiles of HFPO-TA has become an urgent task.In this study,we investigated the cytotoxicity and hepatoxicity of HFPO-TA using human embryonic stem cell(hESC)-based assays.Results showed that HFPO-TA reduced hESCs'vi-ability in a dose dependent manner,and the calculated IC50 for 24,48 and 72 hr were 222.8,167.4,and 80.6 μmol/L,respectively.Significant intracellular ROS accumulation and mito-chondrion membrane potential reduction were detected with HFPO-TA exposure,and in-creased apoptotic/necrotic cells were also observed in high dose of HFPO-TA treated group.Moreover,HFPO-TA at noncytotoxic concentrations also significantly impaired the functions of induced hepatocytes by diminishing cell glycogen storage ability and deregulating specific functional genes.Transcriptome sequencing analysis identified a set of hepatic associated biological processes responding to HFPO-TA exposure.PPAR was the most significantly en-riched pathway.Genes including FGA,FGB,FGG,AHSG,HRG,ITIH2,ALB were characterized as hub genes by cytoHubba plug-in.These data indicated that HFPO-TA is a potential hep-atotoxicant,and may not be a safe replacement for PFOA.
文献关键词：
中图分类号：
作者姓名：
Shengxian Liang;Guoqiang Liang;Yue Zhang;Xiufang Zhang;Li Zhong
作者机构：
Institute of Life Sciences and Green Development,College of Life Sciences,Hebei University,Baoding 071000,China;Western University of Health Sciences,Pomona,California 91766,USA
文献出处：
引用格式：
[1]Shengxian Liang;Guoqiang Liang;Yue Zhang;Xiufang Zhang;Li Zhong-.Profiling biotoxicities of hexafluoropropylene oxide trimer acid with human embryonic stem cell-based assays)[J].环境科学学报（英文版）,2022(06):34-42
A类：
biotoxicities,Hexafluoropropylene,perfluorooc,tanoic,hepatoxicity,chondrion,noncytotoxic,deregulating,ITIH2,atotoxicant
B类：
Profiling,hexafluoropropylene,oxide,trimer,acid,human,embryonic,stem,assays,HFPO,TA,emerging,replacement,PFOA,has,recently,been,reported,potential,environmental,contaminant,Due,similar,structure,may,cause,comparable,adverse,effects,health,Therefore,evaluating,profiles,become,urgent,task,In,this,study,investigated,cytotoxicity,using,Results,showed,that,reduced,hESCs,ability,dose,dependent,manner,calculated,IC50,hr,were,respectively,Significant,intracellular,ROS,accumulation,mito,membrane,reduction,detected,exposure,creased,apoptotic,necrotic,cells,also,observed,high,treated,group,Moreover,concentrations,significantly,impaired,functions,induced,hepatocytes,by,diminishing,glycogen,storage,specific,functional,genes,Transcriptome,sequencing,analysis,identified,set,hepatic,associated,biological,processes,responding,PPAR,was,most,riched,pathway,Genes,including,FGA,FGB,FGG,AHSG,HRG,ALB,characterized,hub,cytoHubba,plug,These,data,indicated,not,safe
AB值：
0.547147
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