典型文献
Microfluidic methods for cell separation and subsequent analysis
文献摘要：
Cell is the most basic unit of the morphological structure and life activity of an organism.Learning the composition,structure and function of cells,exploring the life activities of cells and studying the inter-action between cells are of great significance for human cognition and control of the life activities of or-ganisms.Therefore,rapid,convenient,inexpensive,high-precision and reliable methods of cell separation and analysis are being developed to obtain accurate information for the study of cytology and pathology.Microfluidic chip is a new emerging technology in recent years.It has a micromanufacturing structure,which can not only realize the precise space-time control of fluid and cells,but also reproduces the three-dimensional dynamic microenvironment of cell growth in the body.In addition,the microfluidic chip has unique microphysical properties and facilitates the integration of microdevices,which provides the possi-bility of real-time monitoring,continuous culture,separation and enrichment,and even in situ analysis of cells.In this review,we summarized recent advances in the development of different techniques for cell isolation and analysis on microfluidic platforms.Focus was put on biochemical and physical methods for cell separation on microfluidic chips.Subsequent cell analysis depending on fluorescence,Raman,cytomi-croscopic imaging,mass spectrometry and electrochemical methods also was remarked.Through analyz-ing and learning the advantages and disadvantages of different technologies,we hope that microfluidic chips will continue to be improved and expanded for medical and clinical applications.
文献关键词：
中图分类号：
作者姓名：
Tianyou Chen;Chunxia Huang;Yanran Wang;Jing Wu
作者机构：
School of Science,China University of Geosciences(Beijing),Beijing 100083,China
文献出处：
引用格式：
[1]Tianyou Chen;Chunxia Huang;Yanran Wang;Jing Wu-.Microfluidic methods for cell separation and subsequent analysis)[J].中国化学快报（英文版）,2022(03):1180-1192
A类：
micromanufacturing,cytomi
B类：
Microfluidic,methods,separation,subsequent,analysis,Cell,most,basic,unit,morphological,structure,life,activity,organism,Learning,composition,function,cells,exploring,activities,studying,inter,action,between,are,great,significance,human,cognition,control,ganisms,Therefore,rapid,convenient,inexpensive,high,precision,reliable,being,developed,obtain,accurate,information,cytology,pathology,new,emerging,technology,recent,years,It,has,which,not,only,realize,precise,space,but,also,reproduces,three,dimensional,dynamic,microenvironment,growth,body,In,addition,microfluidic,unique,microphysical,properties,facilitates,integration,microdevices,provides,possi,bility,monitoring,continuous,culture,enrichment,even,situ,this,review,summarized,advances,development,different,techniques,isolation,platforms,Focus,was,put,biochemical,chips,Subsequent,depending,fluorescence,Raman,croscopic,imaging,mass,spectrometry,electrochemical,remarked,Through,analyz,learning,disadvantages,technologies,hope,that,will,continue,improved,expanded,medical,clinical,applications
AB值：
0.607694
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