典型文献
Single-cell metabolite analysis on a microfluidic chip
文献摘要：
Metabolites can directly reflect and modulate cell responses and phenotypical changes by influencing en-ergy balances,intercellular signals,and many other cellular functions throughout the lifespan of cells.Taking into account the heterogeneity of cells,single-cell metabolite analysis offers an insight into the functional process within one cell.Microfluidics as a powerful tool has attracted significant interest in the single-cell metabolite analysis field.The microfluidic platform is possible to observe,classify,and stimulate individual cells.It can also transport single-cell to subsequent analysis steps in a fast and con-trollable way to determine and analyze the composition and content of metabolites.The reviews of topics in microfluidics for single-cell metabolite analysis have been published in the past few years.However,most of them focused on metabolite analysis with mass spectrometry.Here,we covered the advances of microfluidic devices for single-cell metabolite analysis,with a focus on single-cell isolation and manipu-lation.What is more,we summarized the detection methods and applications of single-cell metabolites.
文献关键词：
中图分类号：
作者姓名：
Chenlong Wang;Wanting Hu;Liandi Guan;Xiaoping Yang;Qionglin Liang
作者机构：
Center for Synthetic and Systems Biology,Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology,Ministry of Education,Department of Chemistry,Tsinghua University,Beijing 100084,China;State Key Laboratory of Chemical Oncogenomics,The Graduate School,Tsinghua University,Shenzhen 518055,China
文献出处：
引用格式：
[1]Chenlong Wang;Wanting Hu;Liandi Guan;Xiaoping Yang;Qionglin Liang-.Single-cell metabolite analysis on a microfluidic chip)[J].中国化学快报（英文版）,2022(06):2883-2892
A类：
phenotypical,trollable
B类：
Single,analysis,chip,Metabolites,directly,reflect,modulate,responses,changes,by,influencing,ergy,balances,intercellular,signals,many,other,functions,throughout,lifespan,cells,Taking,into,account,heterogeneity,single,offers,insight,functional,process,within,one,Microfluidics,powerful,tool,has,attracted,significant,interest,field,platform,possible,observe,classify,stimulate,individual,It,also,transport,subsequent,steps,fast,way,determine,analyze,composition,content,metabolites,reviews,topics,microfluidics,have,been,published,past,few,years,However,most,them,focused,mass,spectrometry,Here,covered,advances,devices,isolation,manipu,What,more,summarized,detection,methods,applications
AB值：
0.574852
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