典型文献
Advances in the design and development of SARS?CoV?2 vaccines
文献摘要：
Since the end of 2019, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide. The RNA genome of SARS-CoV-2, which is highly infectious and prone to rapid mutation, encodes both structural and non-structural proteins. Vaccination is currently the only effective method to prevent COVID-19, and structural proteins are critical targets for vaccine development. Currently, many vaccines are in clinical trials or are already on the market. This review highlights ongoing advances in the design of prophylactic or therapeutic vaccines against COVID-19, including viral vector vaccines, DNA vaccines, RNA vaccines, live-attenuated vaccines, inactivated virus vaccines, recombinant protein vaccines and bionic nanoparticle vaccines. In addition to traditional inactivated virus vaccines, some novel vaccines based on viral vectors, nanoscience and synthetic biology also play important roles in combating COVID-19. However, many challenges persist in ongoing clinical trials.
文献关键词：
中图分类号：
作者姓名：
Xue?Liang Peng;Ji?Si?Yu Cheng;Hai?Lun Gong;Meng?Di Yuan;Xiao?Hong Zhao;Zibiao Li;Dai?Xu Wei
作者机构：
Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Department of Life Sciences and Medicine, Northwest University, Xi'an 710069, China;Institute of Materials Research and Engineering, A*STAR (Agency for Science, Technology and Research), 2 Fusionopolis Way, Innovis,#08-03, Singapore 138634, Singapore
文献出处：
引用格式：
[1]Xue?Liang Peng;Ji?Si?Yu Cheng;Hai?Lun Gong;Meng?Di Yuan;Xiao?Hong Zhao;Zibiao Li;Dai?Xu Wei-.Advances in the design and development of SARS?CoV?2 vaccines)[J].军事医学研究（英文）,2022(04):484-513
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B类：
Advances,design,development,SARS,CoV,vaccines,Since,end,coronavirus,disease,caused,by,severe,acute,respiratory,syndrome,has,spread,worldwide,genome,which,highly,infectious,prone,rapid,mutation,encodes,both,structural,proteins,Vaccination,currently,only,effective,method,prevent,are,critical,targets,Currently,many,clinical,trials,already,market,This,review,highlights,ongoing,advances,prophylactic,therapeutic,against,including,viral,live,attenuated,inactivated,recombinant,bionic,nanoparticle,In,addition,traditional,some,novel,vectors,nanoscience,synthetic,biology,also,play,important,roles,combating,However,challenges,persist
AB值：
0.585692
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