典型文献
A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors
文献摘要：
The COVID-19,caused by SARS-CoV-2,is threatening public health,and there is no effective treatment.In this study,we have implemented a multi-targeted anti-viral drug design strategy to discover highly potent SARS-CoV-2 inhibitors,which simultaneously act on the host ribosome,viral RNA as well as RNA-dependent RNA polymerases,and nucleocapsid protein of the virus,to impair viral translation,frameshifting,replication,and assembly.Driven by this strategy,three alkaloids,including lycorine,emetine,and cephaeline,were discovered to inhibit SARS-CoV-2 with EC50 values of low nanomolar levels potently.The findings in this work demonstrate the feasibility of this multi-targeting drug design strategy and provide a rationale for designing more potent anti-virus drugs.
文献关键词：
中图分类号：
作者姓名：
Peng-xuan Ren;Wei-juan Shang;Wan-chao Yin;Huan Ge;Lin Wang;Xiang-lei Zhang;Bing-qian Li;Hong-lin Li;Ye-chun Xu;Eric H.Xu;Hua-liang Jiang;Li-li Zhu;Lei-ke Zhang;Fang Bai
作者机构：
School of Life Science and Technology,and Shanghai Institute for Advanced Immunochemical Studies,ShanghaiTech University,Shanghai 201210,China;State Key Laboratory of Virology,Wuhan Institute of Virology,Center for Biosafety Mega-Science,Chinese Academy of Sciences,Wuhan 430071,China;CAS Key Laboratory of Receptor Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;State Key Laboratory of Bioreactor Engineering,Shanghai Key Laboratory of New Drug Design,School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China;Department of Chemistry,Imperial College London,London,United Kingdom;University of Chinese Academy of Sciences,Beijing 100049,China
文献出处：
引用格式：
[1]Peng-xuan Ren;Wei-juan Shang;Wan-chao Yin;Huan Ge;Lin Wang;Xiang-lei Zhang;Bing-qian Li;Hong-lin Li;Ye-chun Xu;Eric H.Xu;Hua-liang Jiang;Li-li Zhu;Lei-ke Zhang;Fang Bai-.A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors)[J].中国药理学报（英文版）,2022(02):483-493
A类：
frameshifting,lycorine,emetine,cephaeline
B类：
multi,targeting,strategy,identifying,anti,SARS,CoV,inhibitors,caused,by,threatening,public,health,there,effective,treatment,In,this,study,have,implemented,targeted,viral,highly,which,simultaneously,act,host,ribosome,well,dependent,polymerases,nucleocapsid,protein,virus,impair,translation,replication,assembly,Driven,three,alkaloids,including,were,discovered,EC50,values,low,nanomolar,levels,potently,findings,work,demonstrate,feasibility,provide,rationale,designing,more,drugs
AB值：
0.524766
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