典型文献
A broadly neutralizing antibody against SARS-CoV-2 Omicron variant infection exhibiting a novel trimer dimer conformation in spike protein binding
文献摘要：
Dear Editor,
The constant evolution of SARS-CoV-2 has resulted in the emergence of circulating variants during the COVID-19 pandemic.Recently,a newly emerged B.1.1.529(Omicron)variant raised global concern.Compared with the original SARS-CoV-2 strain and other variants of concern(VOCs),the Omicron variant has more than 30 mutations on its spike(S)protein,1 of which 16 mutations are located in the receptor-binding domain(RBD).These muta-tions confer significant resistance to neutralizing antibodies elicited by COVID-19 convalescents2,3 or individuals who have received mRNA vaccines4,5 or inactivated vaccines.6 A recent study indicated that most SARS-CoV-2-specific monoclonal antibodies,including FDA-approved antibodies,have lost efficacy against the Omicron variant.7 The Omicron variant has become the dominant strain worldwide,making it urgent to update the vaccination strategy or develop new antibodies to catch up with the pandemic.
文献关键词：
中图分类号：
作者姓名：
Yingdan Wang;Wuqiang Zhan;Jiangyan Liu;Yanqun Wang;Xiang Zhang;Meng Zhang;Lin Han;Yunping Ma;Lu Lu;Yumei Wen;Zhenguo Chen;Jincun Zhao;Fan Wu;Lei Sun;Jinghe Huang
作者机构：
Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS)and Shanghai Institute of Infectious Disease and Biosecurity,Shanghai Fifth People's Hospital,Shanghai Public Health Clinical Center,Institutes of Biomedical Sciences,School of Basic Medical Sciences,Fudan University,Shanghai,China;Shanghai Immune Therapy Institute,Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital,Shanghai,China;State Key Laboratory of Respiratory Disease,National Clinical Research Center for Respiratory Disease,Guangzhou Institute of Respiratory Health,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou,Guangdong,China;Institute of Infectious Disease,Guangzhou Eighth People's Hospital of Guangzhou Medical University,Guangzhou,Guangdong,China
文献出处：
引用格式：
[1]Yingdan Wang;Wuqiang Zhan;Jiangyan Liu;Yanqun Wang;Xiang Zhang;Meng Zhang;Lin Han;Yunping Ma;Lu Lu;Yumei Wen;Zhenguo Chen;Jincun Zhao;Fan Wu;Lei Sun;Jinghe Huang-.A broadly neutralizing antibody against SARS-CoV-2 Omicron variant infection exhibiting a novel trimer dimer conformation in spike protein binding)[J].细胞研究（英文版）,2022(09):862-865
A类：
convalescents2,vaccines4
B类：
broadly,neutralizing,antibody,against,SARS,CoV,Omicron,infection,exhibiting,novel,trimer,dimer,conformation,spike,protein,binding,Dear,Editor,
The,constant,evolution,has,resulted,emergence,circulating,variants,during,pandemic,Recently,newly,emerged,raised,global,concern,Compared,original,strain,other,VOCs,more,than,mutations,its,which,located,receptor,domain,RBD,These,confer,significant,resistance,antibodies,elicited,by,individuals,who,have,received,inactivated,recent,study,indicated,that,most,specific,monoclonal,including,FDA,approved,lost,efficacy,become,dominant,worldwide,making,urgent,update,vaccination,strategy,develop,catch
AB值：
0.593077
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
