Background Since December 2019,the SARS-CoV-2 virus has been a global health issue.The main clinical presentation of this virus is a flu-like disease;however,patients with diverse neurologic manifestations have also been reported.In this review,we attempt to summarize,discuss and update the knowledge of the neurologic manifestations in the pediatric popula-tion affected by SARS-CoV-2 infection and the pandemic's effects in children with neurologic diseases.Data sources This review analyzes studies found on the PubMed database using the following keywords:Neurologic mani-festations COVID-19,Neurological COVID-19,coronavirus,SARS-CoV-2,pediatric COVID-19,COVID-19 in children,MIS-C,Pediatric Inflammatory Multisystem Syndrome,Guillain Barré Syndrome,Stroke,ADEM,and Anti-NMDA encepha-litis.All studies cited were published between 2004 and 2022,and represent the most relevant articles in the field.The World Health Organization COVID-19 online dashboard was assessed to obtain updated epidemiological data.Results The most common neurologic symptoms in the pediatric population are headache,seizures,encephalopathy,and muscle weakness.These can be present during COVID-19 or weeks after recovering from it.Children who presented with multi-system inflammatory syndrome had a higher incidence of neurologic manifestations,which conferred a greater risk of morbidity and mortality.Several neuro-pathophysiological mechanisms have been proposed,including direct virus invasion,hyper-inflammatory reactions,multi-systemic failure,prothrombotic states,and immune-mediated processes.On the other hand,the COVID-19 pandemic has affected patients with neurologic diseases,making it challenging to access controls,treatment,and therapies.Conclusions Various neurologic manifestations have been associated with children's SARS-CoV-2 infection.It is important to identify and give them proper and opportune treatment because they can be potentially grave and life-threatening;some can lead to long-lasting sequelae.Different neuro-pathophysiological mechanisms have been proposed,however,a causal relationship between SARS-CoV-2 infection and neurologic manifestations remains to be proven.Patients with neurologic diseases are especially affected by COVID-19,not only by the disease itself but also by its complications and pandemic management measures.

Department of Neurology,Hospital Dr.Exequiel González Cortés,Gran Avenida José Miguel Carrera 3300,8900085 Santiago,Región Metropolitana,Chile

[1]Carolina Valderas;Gastón Méndez;Alejandra Echeverría;Nelson Suarez;Katherin Julio;Francisca Sandoval-.COVID-19 and neurologic manifestations:a synthesis from the child neurologist's corner)[J].世界儿科杂志（英文版）,2022(06):373-382

neurologist,Neurologic,festations,Multisystem,encepha,litis,dashboard,opportune

neurologic,manifestations,synthesis,from,corner,Background,Since,December,SARS,CoV,has,been,global,health,issue,clinical,presentation,this,flu,like,however,patients,diverse,have,also,reported,review,attempt,summarize,discuss,knowledge,pediatric,affected,by,infection,pandemic,effects,children,diseases,Data,sources,This,analyzes,studies,found,database,using,following,keywords,Neurological,coronavirus,MIS,Pediatric,Inflammatory,Syndrome,Guillain,Barr,Stroke,ADEM,Anti,NMDA,All,cited,were,published,between,represent,most,relevant,articles,field,World,Health,Organization,online,was,assessed,obtain,updated,epidemiological,Results,common,symptoms,population,are,headache,seizures,encephalopathy,muscle,weakness,These,can,during,weeks,after,recovering,Children,who,presented,multi,inflammatory,syndrome,had,higher,incidence,which,conferred,greater,risk,morbidity,mortality,Several,pathophysiological,mechanisms,proposed,including,direct,invasion,hyper,reactions,systemic,failure,prothrombotic,states,immune,mediated,processes,On,other,hand,making,challenging,access,controls,treatment,therapies,Conclusions,Various,associated,It,important,identify,give,them,proper,because,they,potentially,grave,life,threatening,some,lead,long,lasting,sequelae,Different,causal,relationship,remains,proven,Patients,especially,not,only,itself,but,complications,management,measures

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