典型文献
Antiviral,immunomodulatory,and anticoagulant effects of quercetin and its derivatives:Potential role in prevention and management of COVID-19
文献摘要：
The coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has caused a devastating health crisis worldwide.In this review,we have discussed that prophylactic phytochemical quercetin supplementation in the form of foods or nutraceuticals may help manage the COVID-19 pandemic.The following evidence supports our argu-ment.First,nuclear factor erythroid-derived 2-like 2(NRF2)agonists abrogate replication of SARS-CoV-2 in lung cells,and quercetin is a potent NRF2 agonist.Second,quercetin exerts antiviral activity against several zoonotic coronaviruses,including SARS-CoV-2,mainly by inhibiting the entry of virions into host cells.Third,inflammatory pathways activated by nuclear factor kappa B,inflammasome,and interleukin-6 signals elicit cytokine release syndrome that promotes acute respiratory distress syndrome in patients with COVID-19,and quercetin inhibits these pro-inflammatory signals.Fourth,patients with COVID-19 develop thrombosis,and quercetin mitigates coagulation abnormalities by inhibiting plasma protein disulfide isomerase.This review provides a strong rationale for testing quercetin for the management of COVID-19.
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中图分类号：
作者姓名：
Souparnika H.Manjunath;Rajesh K.Thimmulappa
作者机构：
Department of Biochemistry,Jagadguru Sri Shivanathreeshwara Medical College,Jagadguru Sri Shivarathreeshwara Academy of Higher Education&Research(JSSAHER),Mysore,570015,India
文献出处：
引用格式：
[1]Souparnika H.Manjunath;Rajesh K.Thimmulappa-.Antiviral,immunomodulatory,and anticoagulant effects of quercetin and its derivatives:Potential role in prevention and management of COVID-19)[J].药物分析学报（英文）,2022(01):29-34
A类：
nutraceuticals,argu
B类：
Antiviral,immunomodulatory,anticoagulant,effects,quercetin,derivatives,Potential,role,prevention,management,disease,pandemic,caused,by,severe,acute,respiratory,syndrome,SARS,CoV,infection,has,devastating,health,crisis,worldwide,In,this,review,we,have,discussed,that,prophylactic,phytochemical,supplementation,form,foods,may,help,following,evidence,supports,First,nuclear,erythroid,derived,like,NRF2,agonists,abrogate,replication,lung,cells,potent,Second,exerts,antiviral,activity,against,several,zoonotic,coronaviruses,including,mainly,inhibiting,entry,virions,into,host,Third,inflammatory,pathways,activated,kappa,inflammasome,interleukin,signals,elicit,cytokine,release,promotes,distress,patients,inhibits,these,Fourth,develop,thrombosis,mitigates,coagulation,abnormalities,plasma,protein,disulfide,isomerase,This,provides,strong,rationale,testing
AB值：
0.652281
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