典型文献
RPA-ligation-qPCR combined method for genotyping the SARS-CoV-2 key mutation E484Q
文献摘要：
Two years of the COVID-19 pandemic has caused 444,837,463 cases and 5,998,581 deaths globally(retrieved from on March 7,2022).The infectious agent causing this pandemic,severe acute respira-tory syndrome coronavirus-2(SARS-CoV-2),has evolved and mutated,creating a series of variants,including alpha,beta,delta,and omicron,and seems to coexist with the human race for the long term.The key mutations of these variants were located on the spike protein of the virus,and these variants are generally more infectious[1].Some of the variants have strong immune escape ability,which brings great new challenges to epidemic prevention and control[2].For example,the mutation of L452R enhances the escape ability of the variants from antibodies;the mutation of P681R can indirectly enhance the process of virus invasion mediated by the spike protein and increase infectivity;the mutation E484K/Q plays a pivotal role in evading vaccine immunity,and variants harboring the E484K/Q mutation have shown resistance to neutralizing antibodies induced by previous infection,resulting in a second or third wave of infection in several countries.Developing an efficient genotyping method for the key mutations of SARS-CoV-2 variants will provide strong support for precise epidemic prevention and control and precision medicine of the virus.
文献关键词：
中图分类号：
作者姓名：
Pei Wang;Chenjie Zhao;Qunwei Lu;Xin Liu;Xing Zhang;Song Gao
作者机构：
School of Food Science and Pharmaceutical Engineering,Nanjing Normal University,Nanjing 210023,China;Key Laboratory of Molecular Biophysics of Ministry of Education,Department of Biomedical Engineering,College of Life Science and Technology,Center for Human Genome Research,Huazhong University of Science and Technology,Wuhan 430074,China;Jiangsu Key Laboratory of Marine Biological Resources and Environment,Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening,Co-Innovation Center of Jiangsu Marine Bio-industry Technology,School of Pharmacy,Jiangsu Ocean University,Lianyungang 222005,China
文献出处：
引用格式：
[1]Pei Wang;Chenjie Zhao;Qunwei Lu;Xin Liu;Xing Zhang;Song Gao-.RPA-ligation-qPCR combined method for genotyping the SARS-CoV-2 key mutation E484Q)[J].生物化学与生物物理学报（英文版）,2022(12):1924-1927
A类：
E484Q
B类：
RPA,ligation,qPCR,combined,method,genotyping,SARS,CoV,key,Two,years,pandemic,has,caused,cases,deaths,globally,retrieved,from,March,infectious,agent,causing,this,severe,acute,respira,tory,syndrome,coronavirus,evolved,mutated,creating,series,variants,including,alpha,beta,delta,omicron,seems,coexist,human,race,long,term,mutations,these,were,located,spike,protein,are,generally,more,Some,have,strong,immune,escape,ability,which,brings,great,new,challenges,epidemic,prevention,control,For,example,L452R,enhances,antibodies,P681R,can,indirectly,process,invasion,mediated,by,increase,infectivity,E484K,plays,pivotal,role,evading,vaccine,immunity,harboring,shown,resistance,neutralizing,induced,previous,infection,resulting,second,third,wave,several,countries,Developing,efficient,will,provide,support,precise,precision,medicine
AB值：
0.622284
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