典型文献
Morinda officinalis oligosaccharides increase serotonin in the brain and ameliorate depression via promoting 5-hydroxytryptophan production in the gut microbiota
文献摘要：
Morinda officinalis oligosaccharides(MOO)are an oral drug approved in China for the treat-ment of depression in China.However,MOO is hardly absorbed so that their anti-depressant mechanism has not been elucidated.Here,we show that oral MOO acted on tryptophan → 5-hydroxytryptophan(5-HTP)→ serotonin(5-HT)metabolic pathway in the gut microbiota.MOO could increase tryptophan hydroxylase levels in the gut microbiota which accelerated 5-HTP production from tryptophan;meanwhile,MOO inhibited 5-hydroxytryptophan decarboxylase activity,thus reduced 5-HT generation,and accumulated 5-HTP.The raised 5-HTP from the gut microbiota was absorbed to the blood,and then passed across the blood-brain barrier to improve 5-HT levels in the brain.Additionally,pentasaccharide,as one of the main components in MOO,exerted the significant anti-depressant effect through a mech-anism identical to that of MOO.This study reveals for the first time that MOO can alleviate depression via increasing 5-HTP in the gut microbiota.
文献关键词：
中图分类号：
作者姓名：
Zheng-Wei Zhang;Chun-Sheng Gao;Heng Zhang;Jian Yang;Ya-Ping Wang;Li-Bin Pan;Hang Yu;Chi-Yu He;Hai-Bin Luo;Zhen-Xiong Zhao;Xin-Bo Zhou;Yu-Li Wang;Jie Fu;Pei Han;Yu-Hui Dong;Gang Wang;Song Li;Yan Wang;Jian-Dong Jiang;Wu Zhong
作者机构：
State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences/Peking Union Medical College,Beijing 100050,China;Beijing Institute of Pharmacology and Toxicology,Beijing 100000,China;Beijing Synchrotron Radiation Facility,Institute of High Energy Physics,Chinese Academy of Sciences,Beijing 100049,China;The National Clinical Research Center for Mental Disorders&Beijing Key Laboratory of Mental Disorders,Beijing Anding Hospital,Capital Medical University,Beijing 100088,China;Advanced Innovation Center for Human Brain Protection,Capital Medical University,Beijing 100069,China;School of Pharmaceutical Sciences,Hainan University,Hainan 570228,China;National Engineering Research Center for the Emergence Drugs,Beijing 100000,China
文献出处：
引用格式：
[1]Zheng-Wei Zhang;Chun-Sheng Gao;Heng Zhang;Jian Yang;Ya-Ping Wang;Li-Bin Pan;Hang Yu;Chi-Yu He;Hai-Bin Luo;Zhen-Xiong Zhao;Xin-Bo Zhou;Yu-Li Wang;Jie Fu;Pei Han;Yu-Hui Dong;Gang Wang;Song Li;Yan Wang;Jian-Dong Jiang;Wu Zhong-.Morinda officinalis oligosaccharides increase serotonin in the brain and ameliorate depression via promoting 5-hydroxytryptophan production in the gut microbiota)[J].药学学报（英文版）,2022(08):3298-3312
A类：
Morinda,pentasaccharide
B类：
officinalis,oligosaccharides,increase,serotonin,brain,ameliorate,depression,promoting,hydroxytryptophan,production,gut,microbiota,MOO,are,oral,drug,approved,China,treat,ment,However,hardly,absorbed,that,their,anti,depressant,mechanism,has,not,been,elucidated,Here,show,acted,HTP,metabolic,pathway,could,hydroxylase,levels,which,accelerated,from,meanwhile,inhibited,decarboxylase,activity,thus,reduced,generation,accumulated,raised,was,blood,then,passed,across,barrier,improve,Additionally,main,components,exerted,significant,effect,through,identical,This,study,reveals,first,alleviate,increasing
AB值：
0.454019
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
