典型文献
Gut microbiota drives macrophage-dependent self-renewal of intestinal stem cells via niche enteric serotonergic neurons
文献摘要：
Lgr5+intestinal stem cells(ISCs)reside within specialized niches at the crypt base and harbor self-renewal and differentiation capacities.ISCs in the crypt base are sustained by their surrounding niche for precise modulation of self-renewal and differentiation.However,how intestinal cells in the crypt niche and microbiota in enteric cavity coordinately regulate ISC sternness remains unclear.Here,we show that ISCs are regulated by microbiota and niche enteric serotonergic neurons.The gut microbiota metabolite valeric acid promotes Tph2 expression in enteric serotonergic neurons via blocking the recruitment of the NuRD complex onto Tph2 promoter.5-hydroxytryptamine(5-HT)in turn activates PGE2 production in a PGE2+macrophage subset through its receptors HTR2A/3 A;and PGE2 via binding its receptors EP1/EP4,promotes Wnt/β-catenin signaling in ISCs to promote their self-renewal.Our findings illustrate a complex crosstalk among microbiota,intestinal nerve cells,intestinal immune cells and ISCs,revealing a new layer of ISC regulation by niche cells and microbiota.
文献关键词：
中图分类号：
作者姓名：
Pingping Zhu;Tiankun Lu;Jiayi Wu;Dongdong Fan;Benyu Liu;Xiaoxiao Zhu;Hui Guo;Ying Du;Feng Liu;Yong Tian;Zusen Fan
作者机构：
CAS Key Laboratory of Infection and Immunity,CAS Center for Excellence in Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences,Beijing,China;School of Life Sciences,Zhengzhou University,Zhengzhou,Henan,China;State Key Laboratory of Esophageal Cancer Prevention&Treatment,Zhengzhou University,Zhengzhou,Henan,China;University of Chinese Academy of Sciences,Beijing,China;School of Medicine,Nankai University,94 Weijin Road,Tianjin,China;CAS Key Laboratory of RNA Biology;Institute of Biophysics,Chinese Academy of Sciences,Beijing,China;Research Center of Basic Medicine,Academy of Medical Sciences,Zhengzhou University,Zhengzhou,Henan,China;State Key Laboratory of Membrane Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing,China
文献出处：
引用格式：
[1]Pingping Zhu;Tiankun Lu;Jiayi Wu;Dongdong Fan;Benyu Liu;Xiaoxiao Zhu;Hui Guo;Ying Du;Feng Liu;Yong Tian;Zusen Fan-.Gut microbiota drives macrophage-dependent self-renewal of intestinal stem cells via niche enteric serotonergic neurons)[J].细胞研究（英文版）,2022(06):555-569
A类：
Lgr5+intestinal,sternness,Tph2,PGE2+macrophage
B类：
Gut,microbiota,drives,dependent,self,renewal,stem,cells,via,enteric,serotonergic,neurons,ISCs,reside,within,specialized,niches,crypt,base,harbor,differentiation,capacities,are,sustained,by,their,surrounding,precise,modulation,However,cavity,coordinately,remains,unclear,Here,show,that,regulated,gut,metabolite,valeric,acid,promotes,expression,blocking,recruitment,NuRD,complex,onto,promoter,hydroxytryptamine,turn,activates,production,subset,through,its,receptors,HTR2A,binding,EP1,EP4,Wnt,catenin,signaling,Our,findings,illustrate,crosstalk,among,nerve,immune,revealing,layer,regulation
AB值：
0.475694
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
