典型文献
Fecal transplantation can alleviate tic severity in a Tourette syndrome mouse model by modulating intestinal flora and promoting serotonin secretion
文献摘要：
Background::Tourette syndrome (TS) is a neuropsychiatric disorder with onset in childhood that warrants effective therapies. Gut microbiota can affect central physiology and function via the microbiota-gut-brain axis. Therefore, the gut microbiota plays an important role in some mental illnesses. A small clinical trial showed that fecal microbiota transplantation (FMT) may alleviate TS symptoms in children. Herein, FMT effects and mechanisms were explored in a TS mouse model.Methods::TS mice model (TSMO)
(n = 80) were established with 3,3
＇-iminodipropionitrile, and 80 mice were used as controls. Mice were grouped into eight groups and were subjected to FMT with feces from children or mice with or without TS, or were given probiotics. Fecal specimens were collected 3 weeks after FMT.
16S rRNA sequencing, behavioral observation, and serum serotonin (5-HT) assay were performed. Differences between groups were analyzed using Mann-Whitney
U test and Kolmogorov-Smirnov (KS) tests.
Results::A total of 18 discriminative microbial signatures (linear discriminant analysis score > 3) that varied significantly between TS and healthy mice (CONH) were identified. A significant increase in
Turicibacteraceae and
Ruminococcaceae in TSMO after FMT was observed
(P < 0.05). Compared with non-transplanted TSMO, the symptoms of those transplanted with feces from CONH were alleviated (
W = 336,
P = 0.046). In the probiotic and FMT experiments, the serum 5-HT levels significantly increased in TSMO that received probiotics (KS = 1.423,
P = 0.035) and in those transplanted with feces from CONH (
W= 336.5,
P = 0.046) compared with TSMO without transplantation.
Conclusions::This study suggests that FMT may ameliorate TS by promoting 5-HT secretion, and it provides new insights into the underlying mechanisms of FMT as a treatment for TS.
文献关键词：
Tourette syndrome;Fecal transplantation;Microbiota;Serotonin
中图分类号：
作者姓名：
Li Hua;Wang Yong;Zhao Changying;Liu Jian;Zhang Lei;Li Anyuan
作者机构：
Department of Gastroenterology, Cheeloo Children's Hospital, Shandong University, Jinan, Shandong 250022, China;Department of Laboratory Medicine, School of Stomatology and Medicine, Foshan University, Chancheng District, Foshan, Guangdong 528000, China;Jinan Institute of Paediatric Medicine, Cheeloo Children's Hospital, Shandong University, Jinan, Shandong 250022, China;Microbiome-X, National Institute of Health Data Science of China, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250002, China;Department of Traditional Chinese Medicine, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, China
文献出处：
引用格式：
[1]Li Hua;Wang Yong;Zhao Changying;Liu Jian;Zhang Lei;Li Anyuan-.Fecal transplantation can alleviate tic severity in a Tourette syndrome mouse model by modulating intestinal flora and promoting serotonin secretion)[J].中华医学杂志（英文版）,2022(06):707-713
A类：
TSMO,iminodipropionitrile,Turicibacteraceae
B类：
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,used,controls,Mice,grouped,into,eight,groups,subjected,feces,from,without,given,probiotics,specimens,collected,weeks,after,16S,rRNA,sequencing,behavioral,observation,serum,HT,assay,performed,Differences,between,analyzed,using,Mann,Whitney,Kolmogorov,Smirnov,KS,tests,Results,total,discriminative,microbial,signatures,linear,discriminant,analysis,score,varied,significantly,healthy,CONH,identified,Ruminococcaceae,was,observed,Compared,transplanted,those,alleviated,In,experiments,levels,increased,received,compared,Conclusions,This,study,suggests,ameliorate,provides,new,insights,underlying,treatment,Microbiota,Serotonin
AB值：
0.515026
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
