典型文献
Milled fl axseed-added diets ameliorated hepatic infl ammation by reducing gene expression of TLR4/NF-κB pathway and altered gut microbiota in STZ-induced type 1 diabetic mice
文献摘要：
Flaxseed has displayed the potential beneficial as functional foods. However, most studies focused on effects of flaxseed extracts or ingredients in flaxseed. Besides, few studies showed that flaxseed extracts contributed to anti-type 1 diabetes (T1D), yet the underlying mechanism is still unknown. In the present study, 16.7％ of milled flaxseed (MF)-added diet was given to diabetic mice induced by streptozocin for 6 weeks. The results showed that MF feeding 1) slightly decreased blood glucose levels and improved the ability of glucose tolerance by oral glucose tolerance test, 2) decreased liver tumor necrosis factor-α levels and increased liver glycogen levels with significance via down-regulating TLR4/NF-κB pathways, 3) and significantly altered some beneficial bacteria in gut microbiota. In conclusion, the present study showed that milled flaxseed showed the potential on anti-T1D through anti-inflammation via TLR4/NF-κB and altering the gut microbiota in STZ-induced diabetic mice.
文献关键词：
中图分类号：
作者姓名：
Hui Xia;Xiangling Shi;Beijia Zhou;Jing Sui;Chao Yang;Hechun Liu;Ligang Yang;Shaokang Wang;Guiju Sun
作者机构：
Key Laboratory of Environmental Medicine and Engineering of Ministry of Education,and Department of Nutrition and Food Hygiene,School of Public Health,Southeast University,Nanjing 210009,China;Research Institute for Environment and Health,School of Law and Public Affairs,Nanjing University of Information Science and Technology,Nanjing,Jiangsu,210044,China
文献出处：
引用格式：
[1]Hui Xia;Xiangling Shi;Beijia Zhou;Jing Sui;Chao Yang;Hechun Liu;Ligang Yang;Shaokang Wang;Guiju Sun-.Milled fl axseed-added diets ameliorated hepatic infl ammation by reducing gene expression of TLR4/NF-κB pathway and altered gut microbiota in STZ-induced type 1 diabetic mice)[J].食品科学与人类健康（英文）,2022(01):32-40
A类：
Milled,axseed,infl,ammation,Flaxseed
B类：
added,diets,ameliorated,hepatic,by,reducing,gene,expression,TLR4,altered,gut,microbiota,STZ,induced,type,diabetic,mice,has,displayed,potential,beneficial,functional,foods,However,most,studies,focused,effects,flaxseed,extracts,ingredients,Besides,few,showed,that,contributed,anti,diabetes,T1D,yet,underlying,mechanism,still,unknown,In,present,study,milled,MF,was,given,streptozocin,weeks,results,feeding,slightly,decreased,blood,glucose,levels,improved,ability,tolerance,oral,test,liver,tumor,necrosis,increased,glycogen,significance,via,down,regulating,pathways,significantly,some,bacteria,conclusion,through,inflammation,altering
AB值：
0.505859
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