典型文献
Selenium-enriched and ordinary green tea extracts prevent high blood pressure and alter gut microbiota composition of hypertensive rats caused by high-salt diet
文献摘要：
High-salt diet is well recognized as a risk factor for hypertension,and dietary intervention plays a critical role in the prevention of hypertension.The current study investigated the effects of selenium-enriched green tea(Se-GT)and ordinary green tea(GT)on prevention of hypertension of rats induced by high-salt diet,as well as their potential regulatory and mechanism.Our results showed that GT and Se-GT supplementations significantly prevented the increase of blood pressure(BP),activated the phosphoinosmde-3-kinase/protein kinase B(PI3K/Akt)signaling pathway,and regulated the gene expression related to BP,as well as improved the tissue damage like heart,liver,and kidneys.Besides,the key parameters associated with oxidative stress,inflammation and endothelial dysfunction were also altered by GT and Se-GT treatments.Importantly,GT or Se-GT administration adjusted the diversity and composition of the intestinal flora.Moreover,GT and Se-GT supplementations increased the abundance of beneficial bacteria and reduced the abundance of harmful or conditional pathogenic bacteria.More specifically,GT intake specifically and significantly enriched the relative abundance of Paraprevotella and Bacteroides,whereas Se-GT was characterized by specific and significant enrichment for Allobaculum and Bifidobacterium.Our results proved that dietary supplement of GT and Se-GT remarkably improved the vascular functions and effectively prevented tissue damage by regulation of intestinal flora,and thus preventing hypertension induced by high-salt diet.
文献关键词：
中图分类号：
作者姓名：
Meirong Wu;Xiaobin Wu;Jiangxiong Zhu;Fanglan Li;Xinlin Wei;Yuanfeng Wang
作者机构：
Development Center of Plant Germplasm Resources,College of Life Sciences,Shanghai Normal University,Shanghai 200234,China;Department of Food Science&Technology,School of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai 200240,China
文献出处：
引用格式：
[1]Meirong Wu;Xiaobin Wu;Jiangxiong Zhu;Fanglan Li;Xinlin Wei;Yuanfeng Wang-.Selenium-enriched and ordinary green tea extracts prevent high blood pressure and alter gut microbiota composition of hypertensive rats caused by high-salt diet)[J].食品科学与人类健康（英文）,2022(03):738-751
A类：
supplementations,phosphoinosmde
B类：
Selenium,enriched,ordinary,green,tea,extracts,high,blood,pressure,gut,microbiota,composition,hypertensive,rats,caused,by,salt,High,well,recognized,risk,hypertension,dietary,intervention,plays,critical,role,prevention,current,study,investigated,effects,selenium,GT,induced,their,potential,regulatory,mechanism,Our,results,showed,that,significantly,prevented,activated,kinase,protein,PI3K,Akt,signaling,pathway,regulated,gene,expression,related,improved,tissue,damage,like,heart,liver,kidneys,Besides,key,parameters,associated,oxidative,stress,inflammation,endothelial,dysfunction,were,also,altered,treatments,Importantly,administration,adjusted,diversity,intestinal,flora,Moreover,increased,abundance,beneficial,bacteria,reduced,harmful,conditional,pathogenic,specifically,intake,relative,Paraprevotella,Bacteroides,whereas,was,characterized,enrichment,Allobaculum,Bifidobacterium,remarkably,vascular,functions,effectively,regulation,thus,preventing
AB值：
0.498111
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