Repair of severe skin tissue injury remains a great challenge and wound infection is still a formidable problem.In this study,new macroporous and antibacterial gelatin/alginate(SAG)-based hydrogels for wound repair were designed and developed based on in-situ gas foaming method and ion release strategy as a result of Mg-Cu particles degradation in the hydrogel matrix.The addition of Mg-Cu particles decreased the storage modulus of SAG,maintained its mechanical resilience and enhanced its water-absorbing capability.Moreover,the water vapor transmission rate of SAG added with 2 wt.％Mg-Cu(SAG-2MC)was 124％of that of medical gauze and 804％of commercial TegadermTM film dressing.The bacterial inhibi-tion rates of SAG-2MC against S.aureus,E.coli and P.aeruginosa reached 99.9％±0.1％,98.7％±1.2％and 98.0％±0.7％,respectively,significantly greater than those of the SAG hydrogel and Mg particle-modified hydrogels.In addition,SAG-2MC hydrogel was biocompatible and promoted cell migration.In vivo experiment results indicated that SAG-2MC significantly accelerated the skin wound healing in murine model as demonstrated by higher epidermis thickness,more collagen deposi-tion and enhanced angiogenesis compared with SAG-0MC,SAG-2M and TegadermTM film.In summary,Mg-Cu particles have great potential to modulate the physiochemical and biological properties of SAG hydrogels.Mg-Cu particle-modified SAG hydrogels reveal significant promise in the treatment of severe skin wound or other soft tissue lesions.

Jiewei Yin;Pengcheng Xu;Kang Wu;Huan Zhou;Xiao Lin;Lili Tan;Huilin Yang;Ke Yang;Lei Yang

College of Chemistry,Chemical Engineering and Materials Science,Orthopedic Institute,Soochow University,Suzhou 215006,China;Department of Orthopaedics,The First Affiliated Hospital,Soochow University,Suzhou 215006,China;Center for Health Science and Engineering(CHSE),School of Health Sciences and Biomedical Engineering,Hebei University of Technology,Tianjin 300130,China;Institute of Metal Research,Chinese Academy of Sciences,Shenyang 110016,China

金属学报（英文版）

[1]Jiewei Yin;Pengcheng Xu;Kang Wu;Huan Zhou;Xiao Lin;Lili Tan;Huilin Yang;Ke Yang;Lei Yang-.Macroporous and Antibacterial Hydrogels Enabled by Incorporation of Mg-Cu Alloy Particles for Accelerating Skin Wound Healing)[J].金属学报（英文版）,2022(05):853-866

Macroporous,2MC,TegadermTM,0MC

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