典型文献
A nano-structured TiO2/CuO/Cu2O coating on Ti-Cu alloy with dual function of antibacterial ability and osteogenic activity
文献摘要：
Bacteria-associated infection and poor osseointegration are two main reasons for orthopedic implant failure.Ti-Cu alloy exhibited excellent antibacterial property,but still presented unsatisfied osteogenic activities.Therefore,Ti-Cu alloy was surface modified by an alkali-heat treatment in this paper to im-prove the osteogenic ability without reduction in antibacterial ability.A TiO2/CuO/Cu2O composite coat-ing with nanostructure was deposited on Ti-Cu alloy.The coating showed increased roughness and great hydrophilicity.Antibacterial tests indicated that the modified Ti-Cu alloy exhibited stronger antibacterial ability against Staphylococcus aureus(S.aureus)than Ti-Cu alloy.Meanwhile,cell experiments demon-strated that the composite coating promoted initial adhesion and spreading of MC3T3-E1 cells,enhanced alkaline phosphatase(ALP)activities as well as extracellular matrix(ECM)mineralization,and signif-icantly upregulated osteogenesis-related gene expressions.It was suggested that the nano-structured TiO2/CuO/Cu2O coating on Ti-Cu alloy might provide a potential strategy for orthopedic implant failure.
文献关键词：
中图分类号：
作者姓名：
Yuan Zhang;Shan Fu;Lei Yang;Gaowu Qin;Erlin Zhang
作者机构：
Key Laboratory for Anisotropy and Texture of Materials(MoE),School of Materials Science and Engineering,Northeastern University,Shenyang 110819,China;Research Center for Metallic Wires,Northeastern University,Shenyang 110819,China
文献出处：
引用格式：
[1]Yuan Zhang;Shan Fu;Lei Yang;Gaowu Qin;Erlin Zhang-.A nano-structured TiO2/CuO/Cu2O coating on Ti-Cu alloy with dual function of antibacterial ability and osteogenic activity)[J].材料科学技术（英文版）,2022(02):201-212
A类：
B类：
structured,TiO2,CuO,Cu2O,coating,alloy,dual,function,antibacterial,ability,osteogenic,activity,Bacteria,associated,infection,poor,osseointegration,are,two,main,reasons,orthopedic,implant,failure,exhibited,excellent,property,but,still,presented,unsatisfied,activities,Therefore,was,surface,modified,by,heat,treatment,this,paper,prove,without,reduction,composite,nanostructure,deposited,showed,increased,roughness,great,hydrophilicity,Antibacterial,tests,indicated,that,stronger,against,Staphylococcus,aureus,than,Meanwhile,experiments,demon,strated,promoted,initial,adhesion,spreading,MC3T3,E1,cells,enhanced,alkaline,phosphatase,ALP,well,extracellular,matrix,ECM,mineralization,signif,icantly,upregulated,osteogenesis,related,expressions,It,suggested,might,provide,potential,strategy
AB值：
0.581561
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