典型文献
Biocompatible Poly(ε-caprolactone)-based Shape-memory Polyurethane Composite Scaffold with Bone-induced Activity
文献摘要：
3D porous scaffold could provide suitable bone-like structure for cell adhesion and proliferation;however,surgical suffer-ing from large volume implantation is a great challenge for patients.In this study,a shape programmable porous poly(ε-caprolactone)(PCL)-based polyurethane scaffold with memory effect was synthesized via gas foaming method,using Citrate modified Amorphous calcium Phosphate(CAP)as bioactive factor.The bending experiments indicated that the scaffolds achieved excellent shape-memory effect,which could be influenced by particle weight content.In vitro mineralization results suggested that the deposition of hydroxyapatite was promoted by scaffolds.Additionally,cell assay showed that composite scaffolds presented good cell toxicity and osteogenicity by the differentiation of rat Mesenchymal Stem Cells(rMSCs)into the osteogenic lineage.In the model of rat cranial implantation,the reparative tissue covered the defect site and bone-like structure deposited on the scaffold due to the formation of new bones.In summary,the porous smart shape-memory com-posite scaffolds could be a potential candidate in future distinctive bone repair applications.
文献关键词：
中图分类号：
作者姓名：
Kun Luo;Li Wang;Xiaohu Chen;Xiyang Zeng;Shiyi Zhou;Peicong Zhang;Junfeng Li
作者机构：
College of Materials,Chemistry and Chemical Engineering,Chengdu University of Technology,Chengdu 610059,China
文献出处：
引用格式：
[1]Kun Luo;Li Wang;Xiaohu Chen;Xiyang Zeng;Shiyi Zhou;Peicong Zhang;Junfeng Li-.Biocompatible Poly(ε-caprolactone)-based Shape-memory Polyurethane Composite Scaffold with Bone-induced Activity)[J].仿生工程学报（英文版）,2022(01):167-178
A类：
osteogenicity,rMSCs,reparative
B类：
Biocompatible,caprolactone,Shape,memory,Polyurethane,Composite,Scaffold,Bone,induced,Activity,porous,could,provide,suitable,like,structure,adhesion,proliferation,however,surgical,suffer,from,large,volume,implantation,great,challenge,patients,In,this,study,shape,programmable,PCL,polyurethane,effect,was,synthesized,via,gas,foaming,method,using,Citrate,modified,Amorphous,calcium,Phosphate,CAP,bioactive,bending,experiments,indicated,that,scaffolds,achieved,excellent,which,influenced,by,particle,weight,content,vitro,mineralization,results,suggested,deposition,hydroxyapatite,promoted,Additionally,assay,showed,composite,presented,good,toxicity,differentiation,Mesenchymal,Stem,Cells,into,lineage,model,cranial,tissue,covered,defect,deposited,due,formation,new,bones,summary,smart,potential,candidate,future,distinctive,repair,applications
AB值：
0.617513
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
