典型文献
Doping Gd3+Ion in PDA-PHBV Coating on Ti6Al4V Alloy for Enhancing Corrosion Resistance and Proliferation of Human Gingival Fibroblasts and Human Umbilical Vein Endothelial Cells
文献摘要：
In this study,we fabricated poly(3-hydroxybutyrate-3-hydroxyvalerate)(PHBV)coatings doped with Gd3+(1,5,and 10×10-4 mol/L)on Ti6A14V alloy for the first time to promote soft tissue sealing around dental implants.The corrosion resist-ance of Gd3+-modified PHBV-coated Ti6A14V was studied by electrochemical and immersion tests,respectively,whereas CCK-8 and RT-PCR evaluated the biocompatibility to human gingival fibroblasts(HGFs)and human umbilical vein endothelial cells(HUVECs).It was found that the Gd3+-modified PHBV coating could enhance the corrosion resistance of Ti6A14V.In vitro cell tests showed that PHBV coatings with and without Gd3+addition could promote adhesion and proliferation of HGFs and HUVECs,showing a Gd3+content-dependent manner.Moreover,it was found that the PDA-PHBV@1Gd showed the best proliferation to HGFs by up-regulating gene expressions of VINCULIN,ITGB1,and ITGA3,whereas the best response to HUVECs with the highest gene expression of eNOS and HIF-1α genes was found in the PDA-PHBV@5Gd-coated group.
文献关键词：
中图分类号：
作者姓名：
Sijie Qin;Xiongcheng Xu;Yanjin Lu;Liu Li;Tingting Huang;Jinxin Lin
作者机构：
Key Laboratory of Optoelectronic Materials Chemistry and Physics,Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences,Fuzhou 350002,China;University of the Chinese Academy of Sciences,Beijing 100049,China;Research Center of Oral Tissue Engineering,School and Hospital of Stomatology,Fujian Medical University,Fuzhou 350001,China;College of Chemistry,Fuzhou University,Fuzhou 350108,China
文献出处：
引用格式：
[1]Sijie Qin;Xiongcheng Xu;Yanjin Lu;Liu Li;Tingting Huang;Jinxin Lin-.Doping Gd3+Ion in PDA-PHBV Coating on Ti6Al4V Alloy for Enhancing Corrosion Resistance and Proliferation of Human Gingival Fibroblasts and Human Umbilical Vein Endothelial Cells)[J].金属学报（英文版）,2022(05):812-824
A类：
Gd3+Ion,hydroxyvalerate,Gd3+addition,Gd3+content,VINCULIN
B类：
Doping,PDA,PHBV,Coating,Ti6Al4V,Alloy,Enhancing,Corrosion,Resistance,Proliferation,Human,Gingival,Fibroblasts,Umbilical,Vein,Endothelial,Cells,In,this,study,fabricated,poly,hydroxybutyrate,coatings,doped,Ti6A14V,alloy,first,promote,soft,tissue,sealing,around,dental,implants,corrosion,modified,coated,was,studied,by,electrochemical,immersion,tests,respectively,whereas,CCK,evaluated,biocompatibility,human,gingival,fibroblasts,HGFs,umbilical,vein,endothelial,cells,HUVECs,It,found,that,could,enhance,resistance,vitro,showed,without,adhesion,proliferation,showing,dependent,manner,Moreover,1Gd,best,regulating,expressions,ITGB1,ITGA3,response,highest,eNOS,HIF,genes,5Gd,group
AB值：
0.536596
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
