典型文献
Plasmonic Gold Chip for Multiplexed Detection of Ovarian Cancer Biomarker in Urine
文献摘要：
Human epididymal protein 4(HE4),carbohydrate antigen 125(CA125)and osteopontin(OPN)are three key biomarkers in detecting ovarian cancer.To explore the diagnosis value of combined detection of these three biomarkers for ovarian cancer,we developed a multiplexed assay on a plasmonic gold(pGOLD)platform for measuring HE4,CA125 and OPN in urine.The receiver operator characteristic(ROC)curve was drawn,and the diagnosis values of each biomarker alone or in combination for ovarian cancer were evaluated.In the analysis to distinguish ovarian cancer from other gynecological cancers,ovarian cysts and healthy people,the sensitivities of HE4,CA125 and OPN were 72.55％,52.82％and 68.63％,the specificity values were 95.06％,87.65％and 90.12％,while the areas under the curve(AUC)were 0.85,0.75 and 0.77,respectively.The sensitivity and specificity for combination detection of the three markers were 90.20％and 80.25％.The detection methods of HE4,CA125 and OPN based on plasma fluorescence enhanced chip showed good analytic and diagnostic performance,and provided a non-invasive method for the diagnosis of ovarian cancer.
文献关键词：
中图分类号：
作者姓名：
CHEN Minwen;LIAO Tao;ZENG Linsheng;ZENG Zhongyi;YANG Qinglai;WANG Guoxin
作者机构：
WWHS Biotech.Inc.,Shenzhen 518000,P.R.China;Shenzhen Traditional Chinese Medicine Hospital,Shenzhen 518033,P.R.China;Center for Molecular Imaging Probe,Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology,Cancer Research Institute,School of Preclinical Medicine,Hengyang Medical School,University of South China,Hengyang 421001,P.R.China
文献出处：
引用格式：
[1]CHEN Minwen;LIAO Tao;ZENG Linsheng;ZENG Zhongyi;YANG Qinglai;WANG Guoxin-.Plasmonic Gold Chip for Multiplexed Detection of Ovarian Cancer Biomarker in Urine)[J].高等学校化学研究（英文版）,2022(04):935-940
A类：
pGOLD
B类：
Plasmonic,Gold,Chip,Multiplexed,Detection,Ovarian,Cancer,Biomarker,Urine,Human,epididymal,protein,HE4,carbohydrate,antigen,CA125,osteopontin,OPN,three,key,biomarkers,detecting,ovarian,To,explore,diagnosis,combined,detection,these,developed,multiplexed,assay,plasmonic,gold,platform,measuring,urine,receiver,operator,characteristic,curve,was,drawn,values,each,alone,combination,were,evaluated,In,analysis,distinguish,from,other,gynecological,cancers,cysts,healthy,people,sensitivities,specificity,while,areas,under,respectively,sensitivity,methods,plasma,fluorescence,enhanced,chip,showed,good,analytic,diagnostic,performance,provided,invasive
AB值：
0.56721
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