典型文献
Dual microenvironmental parameter-responsive lysosome-targeting carbon dots for the high contrast discrimination of a broad spectrum of cancer cells
文献摘要：
The development of new carbon dots(CDs)for fluorescence-based cancer diagnosis has recently attracted extensive attention.Diagnosis methods based on ligand-receptor fluorescence suffer from the heterogene-ity of receptor expression.Changes in the microenvironments of cancer cells provide opportunities for ac-curate and broad-spectrum cancer diagnosis.The lysosomes in cancer cells have lower polarity and higher viscosity than normal cells.Based on these two key microenvironmental parameters,dual-responsive CDs with inherent lysosome-targeting ability were synthesized via one-step hydrothermal treatment.The CDs exhibit many advantageous properties including facile synthesis,good water solubility,pH-independent emission,excellent photostability,good biocompatibility,and wash-free imaging ability.The CDs were successfully employed in the fluorescence-based discrimination of a broad spectrum of cancer cells from normal cells with high contrast.The CDs are promising candidates for use in the field of cancer diagnosis.
文献关键词：
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作者姓名：
Yue Xiao;Xiaohui Yin;Pengjuan Sun;Yuanqiang Sun;Lingbo Qu;Zhaohui Li
作者机构：
College of Chemistry,Institute of Analytical Chemistry for Life Science,Henan Joint International Research Laboratory of Green Construction of Functional Molecules and Their Bioanalytical Applications,Zhengzhou University,Zhengzhou 450001,China
文献出处：
引用格式：
[1]Yue Xiao;Xiaohui Yin;Pengjuan Sun;Yuanqiang Sun;Lingbo Qu;Zhaohui Li-.Dual microenvironmental parameter-responsive lysosome-targeting carbon dots for the high contrast discrimination of a broad spectrum of cancer cells)[J].中国化学快报（英文版）,2022(12):5051-5055
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Dual,microenvironmental,responsive,targeting,carbon,dots,contrast,discrimination,broad,spectrum,cancer,cells,development,new,CDs,fluorescence,diagnosis,has,recently,attracted,extensive,attention,Diagnosis,methods,ligand,receptor,suffer,from,heterogene,expression,Changes,microenvironments,provide,opportunities,curate,lysosomes,have,lower,polarity,higher,viscosity,than,normal,Based,these,two,key,parameters,dual,inherent,were,synthesized,via,one,step,hydrothermal,treatment,exhibit,many,advantageous,properties,including,facile,synthesis,good,water,solubility,independent,emission,excellent,photostability,biocompatibility,wash,free,imaging,successfully,employed,are,promising,candidates,use,field
AB值：
0.585469
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