典型文献
A Long-wavelength Emissive Phenothiazine Derived Fluorescent Probe for Detecting HOCI Upregulation in 5-FU Stimulated Living Cells
文献摘要：
The endogenous hypochlorous acid(HOCI)has been evidenced in a variety of cellular courses.However,the role of HOCI in most pathophysiological processes still keeps unclear because of the limited detecting tools.In this work,we presented the pre-paration of a phenothiazine-derived fluorescent probe CIO-1 for HOCI detection with a cyanopyridinium moiety to improve its water solubility and lengthen its emission wavelength.The HOCI-pro-moted oxidation of sulfur atom in the probe resulted in a 460-fold emission intensity enhancement at 635 nm with high selectivity and sensitivity(detection limit:1.12 nmol/L).The rapid response(5 s)also endowed the probe with real-time detection ability.Success-fully,CIO-1 was devoted to the bioimaging of endogenous HOCI in inflamed RAW 264.7 cells and 5-fluorouracil-treated MCF-7 cells.
文献关键词：
中图分类号：
作者姓名：
WANG Bingya;GUO Xiaomei;LIU Zuodong;WU Yongquan;HOU Ji-Ting
作者机构：
College of Chemistry and Chemical Engineering,Xinyang Normal Uni-versity,Xinyang 464000,P.R.China;School of Chemistry and Chemical Engineering,Gannan Normal Uni-versity,Ganzhou 341000,P.R.China;Henan Key Laboratory of Utilization of Non-metallic Mineral in the South of Henan,Xinyang Normal University,Xinyang 464000,P.R.China
文献出处：
引用格式：
[1]WANG Bingya;GUO Xiaomei;LIU Zuodong;WU Yongquan;HOU Ji-Ting-.A Long-wavelength Emissive Phenothiazine Derived Fluorescent Probe for Detecting HOCI Upregulation in 5-FU Stimulated Living Cells)[J].高等学校化学研究（英文版）,2022(02):609-615
A类：
Phenothiazine,HOCI,hypochlorous,paration,phenothiazine,cyanopyridinium
B类：
Long,wavelength,Emissive,Derived,Fluorescent,Probe,Detecting,Upregulation,FU,Stimulated,Living,Cells,endogenous,acid,has,been,evidenced,variety,cellular,courses,However,role,most,pathophysiological,processes,still,keeps,unclear,because,limited,detecting,tools,In,this,work,presented,derived,fluorescent,probe,CIO,detection,moiety,improve,its,water,solubility,lengthen,emission,moted,oxidation,sulfur,atom,resulted,fold,intensity,enhancement,high,selectivity,sensitivity,nmol,rapid,response,also,endowed,real,ability,Success,fully,was,devoted,bioimaging,inflamed,RAW,cells,fluorouracil,treated,MCF
AB值：
0.615886
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