典型文献
Rational design of shortwave infrared(SWIR)fluorescence probe:Cooperation of ICT and ESIPT processes for sensing endogenous cysteine
文献摘要：
Cysteine is well-known to be an important biothiol and related to many diseases.However,the in vivo detection of endogenous cysteine still suffers from lacking small-molecule fluorophores with both exci-tation and emission in the near-infrared(650-900 nm)/shortwave-infrared region.Herein,we report a molecular engineering strategy for shortwave infrared(SWIR,900-1700 nm)sensing of cysteine,which integrated an excited-state intermolecular proton transfer(ESIPT)building block into the intramolecular charge transfer(ICT)scaffold.The obtained novel fluorophore SH-OH displays a maximum absorption at the NIR region,and emission at the SWIR region.We introduce the cysteine-recognition moiety to SH-OH structure,and demonstrate sensing of endogenous cysteine in living animals,using the SWIR emission as a reliable off-on fluorescence signal.This fluorophore design strategy of cooperation of ICT and ESIPT processes expands the in vivo sensing toolbox for accurate analysis in clinical applications.
文献关键词：
中图分类号：
作者姓名：
Maoju Chang;Chenxu Yan;Lei Shi;Dan Li;Wei Fu;Zhiqian Guo
作者机构：
Shanghai Key Laboratory of Functional Materials Chemistry,Key Laboratory for Advanced Materials and Institute of Fine Chemicals,Joint International Research Laboratory of Precision Chemistry and Molecular Engineering,Feringa Nobel Prize Scientist Joint Research Center,Frontiers Science Center for Materiobiology and Dynamic Chemistry,School of Chemistry and Molecular Engineering,East China University of Science and Technology,Shanghai 200237,China
文献出处：
引用格式：
[1]Maoju Chang;Chenxu Yan;Lei Shi;Dan Li;Wei Fu;Zhiqian Guo-.Rational design of shortwave infrared(SWIR)fluorescence probe:Cooperation of ICT and ESIPT processes for sensing endogenous cysteine)[J].中国化学快报（英文版）,2022(02):762-766
A类：
biothiol
B类：
Rational,design,shortwave,infrared,SWIR,fluorescence,probe,Cooperation,ICT,ESIPT,processes,sensing,endogenous,cysteine,Cysteine,well,known,important,related,many,diseases,However,vivo,detection,still,suffers,from,lacking,small,molecule,fluorophores,both,tation,emission,near,region,Herein,report,engineering,strategy,which,integrated,excited,state,intermolecular,proton,transfer,building,block,into,intramolecular,charge,scaffold,obtained,novel,SH,displays,maximum,absorption,NIR,We,introduce,recognition,moiety,structure,demonstrate,living,animals,using,reliable,off,signal,This,cooperation,expands,toolbox,accurate,analysis,clinical,applications
AB值：
0.547281
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