典型文献
A melatonin-based targetable fluorescent probe for screening of tumor cells and real-time imaging of glutathione fluctuations in tumor cells
文献摘要：
Glutathione(GSH)is a key maintainer of cellular redox balance and plays an important role in many physiological effects.For example,GSH has been widely implicated in cancer initiation,progression and metastasis.Moreover,the concentrations of GSH in tumor cells can influence drug resistance.Given the serious harmfulness of cancer and the important roles of GSH in cancer,it has great significance to devel-opment probes for screening of tumor cells and real-time monitoring of GSH fluctuations in tumor cells.However,no targetable probe for reversible imaging of GSH in tumor cells has been reported.Herein,we constructed a melatonin-based targetable and reversible fluorescent probe(GR-MT)for screening of tumor cells and real-time imaging of GSH fluctuations in tumor cells.The probe uses coumarin as the skeleton,Michael addition reaction as the reaction mechanism,and melatonin as the targeted groups of tumor cells.The experimental results demonstrate this probe has many advantages including high selec-tivity,satisfactory sensitivity,excellent reversible ability,rapid reaction speed,and outstanding targetabil-ity of tumor cells.Therefore,this study provides a promising tool for tumor cells screening and real-time detection of GSH fluctuations in specific tumor cells.
文献关键词：
中图分类号：
作者姓名：
Xiwei Li;Caiyun Liu;Na Gao;Wenlong Sheng;Baocun Zhu
作者机构：
School of Water Conservancy and Environment,University of Jinan,Ji'nan 250022,China;Biology Institute,Qilu University of Technology(Shandong Academy of Sciences),Ji'nan 250103,China
文献出处：
引用格式：
[1]Xiwei Li;Caiyun Liu;Na Gao;Wenlong Sheng;Baocun Zhu-.A melatonin-based targetable fluorescent probe for screening of tumor cells and real-time imaging of glutathione fluctuations in tumor cells)[J].中国化学快报（英文版）,2022(05):2527-2531
A类：
targetable,maintainer,harmfulness,targetabil
B类：
melatonin,fluorescent,screening,tumor,cells,real,imaging,glutathione,fluctuations,Glutathione,GSH,key,cellular,redox,balance,plays,important,many,physiological,effects,For,example,has,been,widely,implicated,cancer,initiation,progression,metastasis,Moreover,concentrations,influence,drug,resistance,Given,serious,roles,great,significance,devel,opment,probes,monitoring,However,no,reversible,reported,Herein,constructed,GR,MT,uses,coumarin,skeleton,Michael,addition,reaction,mechanism,targeted,groups,experimental,results,demonstrate,this,advantages,including,high,selec,satisfactory,sensitivity,excellent,ability,rapid,speed,outstanding,Therefore,study,provides,promising,tool,detection,specific
AB值：
0.455767
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