典型文献
Lysosome-targeting red fluorescent probe for broad carboxylesterases detection in breast cancer cells
文献摘要：
Available online The abnormal carboxylesterase(CES)expression is closely related to many diseases such as hyperlipidemia,atherosclerosis,obesity,liver cancer,type 2 diabetes mellitus and gastrointestinal stro-mal tumors.The detection of a single enzyme in practical samples is often constrained by the structural diversity of CESs.Thus,the development of broad-carboxylesterase responsive fluorescent probe,which can detect the presence of wide variety of CESs,may provide overall or category information from another point of view,supplementing the deficiency of single detection for CES subspecies.Organelle lysosome is involved in various cell processes,such as cell signaling,apoptosis,secretion,and energy metabolism.Up to date,lysosome-targeted fluorescent probes,especially those with red emission(over 550 nm,with rel-atively low biological harmfulness),for CES detection are still rare.A lysosomes-targeted red fluorescent probe CES-Lyso was designed to monitor intracellular a variety of carboxylesterases alteration with won-derful selectivity and sensitivity,which was further applied to distinguish different derived breast cancer cells and monitor carboxylesterase activity in the anticancer drug treatment.
文献关键词：
中图分类号：
作者姓名：
Yanyan Sun;Xiaonan Zhou;Liyuan Sun;Xiuxiu Zhao;Yongrui He;Ge Gao;Weina Han;Jin Zhou
作者机构：
School of Pharmacy,School of Rehabilitation Medicine,Weifang Medical University,Weifang 261053,China;Weifang Maternal and Child Health Hospital,Maternal and Child Health Hospital of Weifang Medical University,Weifang 261011,China
文献出处：
引用格式：
[1]Yanyan Sun;Xiaonan Zhou;Liyuan Sun;Xiuxiu Zhao;Yongrui He;Ge Gao;Weina Han;Jin Zhou-.Lysosome-targeting red fluorescent probe for broad carboxylesterases detection in breast cancer cells)[J].中国化学快报（英文版）,2022(09):4229-4232
A类：
carboxylesterases,harmfulness,derful
B类：
Lysosome,targeting,red,fluorescent,broad,detection,breast,cells,Available,online,abnormal,expression,closely,related,many,diseases,such,hyperlipidemia,atherosclerosis,obesity,liver,type,diabetes,mellitus,gastrointestinal,tumors,single,enzyme,practical,samples,often,constrained,by,structural,diversity,CESs,Thus,development,responsive,which,presence,wide,variety,may,provide,overall,category,information,from,another,point,view,supplementing,deficiency,subspecies,Organelle,involved,various,processes,signaling,apoptosis,secretion,energy,metabolism,Up,date,targeted,probes,especially,those,emission,atively,low,biological,still,rare,lysosomes,was,designed,monitor,intracellular,alteration,won,selectivity,sensitivity,further,applied,distinguish,different,derived,activity,anticancer,drug,treatment
AB值：
0.559286
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