典型文献
Di-4-ANEPPDHQ probes the response of lipid packing to the membrane tension change in living cells
文献摘要：
Membrane tension plays a significant role in many cellular processes including cell adhesion,migration and spreading.Despite the importance of membrane tension,it remains difficult to measure in vivo.Re-cently,the development of non-invasive fluorescent probes have made great progress,especially excited-state deplanarization in molecular rotors has been applied to image membrane tension in living cells.Nevertheless,an intrinsic limitation of such kind of probe is that they depend on the lipid packing,and how the lipid packing responds to the membrane tension change remains unclear.Therefore,in this work,we used a polarity-sensitive membrane probe to investigate the possible response mechanism of lipid packing to the change of membrane tension that was regulated by osmotic shocks.The results showed that an increase in membrane tension could stretch the lipids apart with large displacements,and this change was not homogeneous on the whole membrane,instead,increase of membrane tension induced phase separation.
文献关键词：
中图分类号：
作者姓名：
Nan Li;Weifei Zhang;Haifeng Lin;Jin-Ming Lin
作者机构：
Beijing Key Laboratory of Microanalytical Methods and Instrumentation,MOE Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology,Department of Chemistry,Tsinghua University,Beijing 100084,China;Division of Chemical Metrology and Analytical Science,National Institute of Metrology,Beijing 100029,China
文献出处：
引用格式：
[1]Nan Li;Weifei Zhang;Haifeng Lin;Jin-Ming Lin-.Di-4-ANEPPDHQ probes the response of lipid packing to the membrane tension change in living cells)[J].中国化学快报（英文版）,2022(03):1377-1380
A类：
ANEPPDHQ,deplanarization
B类：
Di,probes,response,packing,membrane,tension,change,living,cells,Membrane,plays,significant,role,many,cellular,processes,including,adhesion,migration,spreading,Despite,importance,remains,difficult,measure,vivo,Re,cently,development,invasive,fluorescent,have,made,great,progress,especially,excited,state,molecular,rotors,been,applied,image,Nevertheless,intrinsic,limitation,such,kind,that,they,depend,responds,unclear,Therefore,this,work,used,polarity,sensitive,investigate,possible,mechanism,was,regulated,by,osmotic,shocks,results,showed,increase,could,stretch,lipids,apart,large,displacements,not,homogeneous,whole,instead,induced,phase,separation
AB值：
0.561027
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