典型文献
Mitochondrial ACOD1/IRG1 in infection and sterile inflammation
☆
文献摘要：
Immunometabolism is a dynamic process involving the interplay of metabolism and immune response in health and diseases. Increasing evidence suggests that impaired immunometabolism contributes to infectious and inflammatory diseases. In particular, the mitochondrial enzyme aconitate decarboxylase 1 (ACOD1, best known as immunoresponsive gene 1 [IRG1]) is upregulated under various inflammatory conditions and serves as a pivotal regulator of immunometabolism involved in itaconate production, macrophage polarization, inflammasome activation, and oxidative stress. Consequently, the activation of the ACOD1 pathway is implicated in regulating the pathogenic process of sepsis and septic shock, which are part of a clinical syndrome of life-threatening organ failure caused by a dysregulated host response to pathogen infection. In this review, we discuss the latest research advances in ACOD1 expression and function, with particular attention to how the ACOD1-itaconate pathway affects infection and sterile inflammation diseases. These new insights may give us a deeper understanding of the role of immunometabolism in innate immunity.
文献关键词：
Aconitate decarboxylase 1 (ACOD1);Sepsis;Inflammation;Metabolism;Disease
中图分类号：
作者姓名：
Wu Runliu;Kang Rui;Tang Daolin
作者机构：
Department of Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410008, China;Department of Surgery, UT Southwestern Medical Center, Dallas, Texas 75390, USA
文献出处：
引用格式：
[1]Wu Runliu;Kang Rui;Tang Daolin-.Mitochondrial ACOD1/IRG1 in infection and sterile inflammation
☆)[J].重症医学（英文）,2022(02):78-88
A类：
ACOD1,inflammation
,Immunometabolism,immunoresponsive,Aconitate
B类：
Mitochondrial,IRG1,infection,sterile,dynamic,process,involving,interplay,immune,response,health,diseases,Increasing,evidence,suggests,that,impaired,immunometabolism,contributes,infectious,inflammatory,particular,mitochondrial,enzyme,aconitate,decarboxylase,best,known,gene,upregulated,various,conditions,serves,pivotal,regulator,involved,itaconate,production,macrophage,polarization,inflammasome,activation,oxidative,stress,Consequently,pathway,implicated,regulating,pathogenic,sepsis,septic,shock,which,are,clinical,syndrome,life,threatening,organ,failure,caused,by,dysregulated,host,this,review,we,discuss,latest,research,advances,expression,function,attention,how,affects,These,new,insights,may,give,deeper,understanding,role,innate,immunity,Sepsis,Inflammation,Metabolism,Disease
AB值：
0.58967
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
