典型文献
CXCR6-based immunotherapy in autoimmune,cancer and inflammatory infliction
文献摘要：
T cells,including both CD4+and CD8+T cells,play a pivotal role in mediating various inflammation and immune disorders.A long-standing challenge in T cell-based immunotherapy is to pre-cisely inactivate or delete the pathogenic T cells in inflammation and autoimmune diseases,or to selec-tively expand the immunocompetent T cell in tumor or other immune compromised situations,without inducing global immunosuppression or zealous immune activation respectively.To achieve this,a specific marker is needed to differentiate the pathogenic or immunocompetent T cell among the rests.Indeed,recent progress of immunology strongly suggests that CXC chemokine receptor 6(CXCR6,CD 186)is such a kind of marker.Here,we review the emerging role of CXCR6 as a novel target for immunotherapy and discuss the underlying mechanism.We propose that CXCR6-based immunotherapy will play a sig-nificant role in autoimmune,nonalcoholic steatohepatitis(NASH),tumor,coronavirus disease 2019(COVID-19)and even ageing-related inflammatory infliction.
文献关键词：
中图分类号：
作者姓名：
Tingting Li;Jie Pan;Hongqi Chen;Yongliang Fang;Yang Sun
作者机构：
Department of Gastroenterology,the Second Medical Center National Clinical Research Center for Geriatric Diseases,State Key Laboratory of Kidney Diseases,Chinese PLA General Hospital,Beijing 100853,China;State Key Laboratory of Pharmaceutical Biotechnology,Department of Biotechnology and Pharmaceutical Sciences,School of Life Sciences,Nanjing University,Nanjing 210023,China;Department of General Surgery,Shanghai Jiao Tong University Affiliated Sixth People's Hospital,Shanghai 200233,China;Department of Urology,Boston Children's Hospital,Departments of Microbiology and Surgery,Harvard Medical School,Boston,MA 02115,USA;Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy,Xuzhou Medical University,Xuzhou 221004,China
文献出处：
引用格式：
[1]Tingting Li;Jie Pan;Hongqi Chen;Yongliang Fang;Yang Sun-.CXCR6-based immunotherapy in autoimmune,cancer and inflammatory infliction)[J].药学学报（英文版）,2022(08):3255-3262
A类：
infliction,zealous
B类：
CXCR6,immunotherapy,autoimmune,cancer,inflammatory,cells,including,both,CD4+and,CD8+T,play,pivotal,role,mediating,various,inflammation,disorders,long,standing,challenge,cisely,inactivate,delete,pathogenic,diseases,selec,expand,immunocompetent,tumor,compromised,situations,without,inducing,global,immunosuppression,activation,respectively,To,achieve,this,specific,marker,needed,differentiate,among,rests,Indeed,recent,progress,immunology,strongly,suggests,that,chemokine,receptor,such,kind,Here,we,review,emerging,novel,target,discuss,underlying,mechanism,We,propose,will,sig,nificant,nonalcoholic,steatohepatitis,NASH,coronavirus,even,ageing,related
AB值：
0.588382
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