典型文献
Role of neutrophil extracellular traps in inflammatory evolution in severe acute pancreatitis
文献摘要：
Severe acute pancreatitis (SAP) is a life-threatening acute abdominal disease with two peaks of death: the first in the early stage, characterized by systemic inflammatory response-associated organ failure; and the second in the late stage, characterized by infectious complications. Neutrophils are the main immune cells participating in the whole process of SAP. In addition to the traditional recognition of neutrophils as the origination of chemokine and cytokine cascades or phagocytosis and degranulation of pathogens, neutrophil extracellular traps (NETs) also play an important roles in inflammatory reactions. We reviewed the role of NETs in the occurrence and development of SAP and its fatal complications, including multiple organs injury, infected pancreatic necrosis, and thrombosis. This review provides novel insights into the involvement of NETs throughout the entire process of SAP, showing that targeting NETs might be a promising strategy in SAP treatment. However, precision therapeutic options targeting NETs in different situations require further investigation.
文献关键词：
Inflammation;Neutrophil extracellular traps;Organ injury;Sepsis;Severe acute pancreatitis;Thrombus
中图分类号：
作者姓名：
Kang Hongxin;Yang Yue;Zhu Lv;Zhao Xianlin;Li Juan;Tang Wenfu;Wan Meihua
作者机构：
Department of Integrated Traditional Chinese and Western Medicine, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China
文献出处：
引用格式：
[1]Kang Hongxin;Yang Yue;Zhu Lv;Zhao Xianlin;Li Juan;Tang Wenfu;Wan Meihua-.Role of neutrophil extracellular traps in inflammatory evolution in severe acute pancreatitis)[J].中华医学杂志（英文版）,2022(23):2773-2784
A类：
Thrombus
B类：
Role,extracellular,traps,inflammatory,evolution,severe,acute,pancreatitis,Severe,SAP,life,threatening,abdominal,disease,two,peaks,death,first,early,stage,characterized,by,systemic,response,associated,failure,second,late,infectious,complications,Neutrophils,are,main,immune,cells,participating,whole,process,addition,traditional,recognition,neutrophils,origination,chemokine,cytokine,cascades,phagocytosis,degranulation,pathogens,NETs,also,play,important,roles,reactions,We,reviewed,occurrence,development,its,fatal,including,multiple,organs,injury,infected,pancreatic,necrosis,thrombosis,This,provides,novel,insights,into,involvement,throughout,entire,showing,that,targeting,might,be,promising,strategy,treatment,However,precision,therapeutic,options,different,situations,require,further,investigation,Inflammation,Organ,Sepsis
AB值：
0.640971
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
