典型文献
The cGAS-STING signaling in cardiovascular and metabolic diseases:Future novel target option for pharmacotherapy
文献摘要：
The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling exert essential regulatory function in microbial-and onco-immunology through the induction of cyto-kines,primarily type Ⅰ interferons.Recently,the aberrant and deranged signaling of the cGAS-STING axis is closely implicated in multiple sterile inflammatory diseases,including heart failure,myocardial infarction,cardiac hypertrophy,nonalcoholic fatty liver diseases,aortic aneurysm and dissec-tion,obesity,etc.This is because of the massive loads of damage-associated molecular patterns(mito-chondrial DNA,DNA in extracellular vesicles)liberated from recurrent injury to metabolic cellular organelles and tissues,which are sensed by the pathway.Also,the cGAS-STING pathway crosstalk with essential intracellular homeostasis processes like apoptosis,autophagy,and regulate cellular metabolism.Targeting derailed STING signaling has become necessary for chronic inflammatory diseases.Mean-while,excessive type Ⅰ interferons signaling impact on cardiovascular and metabolic health remain entirely elusive.In this review,we summarize the intimate connection between the cGAS-STING pathway and cardiovascular and metabolic disorders.We also discuss some potential small molecule in-hibitors for the pathway.This review provides insight to stimulate interest in and support future research into understanding this signaling axis in cardiovascular and metabolic tissues and diseases.
文献关键词：
中图分类号：
作者姓名：
Patrick Kwabena Oduro;Xianxian Zheng;Jinna Wei;Yanze Yang;Yuefei Wang;Han Zhang;Erwei Liu;Xiumei Gao;Mei Du;Qilong Wang
作者机构：
Institute of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;State Key Laboratory of Component-Based Chinese Medicine,Ministry of Education,Tianjin 301617,China;Department of Pharmacology and Tianjin Key Laboratory of Inflammation Biology,School of Basic Medical Sciences,Tianjin Medical University,Tianjin 300070,China
文献出处：
引用格式：
[1]Patrick Kwabena Oduro;Xianxian Zheng;Jinna Wei;Yanze Yang;Yuefei Wang;Han Zhang;Erwei Liu;Xiumei Gao;Mei Du;Qilong Wang-.The cGAS-STING signaling in cardiovascular and metabolic diseases:Future novel target option for pharmacotherapy)[J].药学学报（英文版）,2022(01):50-75
A类：
onco,kines,deranged,derailed
B类：
cGAS,STING,signaling,cardiovascular,metabolic,diseases,Future,novel,target,option,pharmacotherapy,cyclic,GMP,AMP,synthase,stimulator,genes,exert,essential,regulatory,function,microbial,immunology,through,induction,cyto,primarily,type,interferons,Recently,aberrant,axis,closely,implicated,multiple,sterile,inflammatory,including,heart,failure,myocardial,infarction,cardiac,hypertrophy,nonalcoholic,fatty,liver,aortic,aneurysm,dissec,obesity,etc,This,because,massive,loads,damage,associated,molecular,patterns,mito,chondrial,extracellular,vesicles,liberated,from,recurrent,injury,organelles,tissues,which,are,sensed,by,pathway,Also,crosstalk,intracellular,homeostasis,processes,like,apoptosis,autophagy,regulate,metabolism,Targeting,become,necessary,chronic,Mean,while,excessive,impact,health,remain,entirely,elusive,In,this,review,summarize,intimate,connection,between,disorders,We,also,discuss,some,potential,small,molecule,hibitors,provides,insight,stimulate,interest,support,future,research,into,understanding
AB值：
0.634232
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
