典型文献
Metabolic regulation of immune responses to cancer
文献摘要：
The tumor microenvironment is an ecosystem composed of multiple types of cells, such as tumor cells, immune cells, and cancer-associated fibroblasts. Cancer cells grow faster than non-cancerous cells and consume larger amounts of nutrients. The rapid growth characteristic of cancer cells fundamentally alters nutrient availability in the tumor microenvironment and results in reprogramming of immune cell metabolic pathways. Accumulating evidence suggests that cellular metabolism of nutrients, such as lipids and amino acids, beyond being essential to meet the bioenergetic and biosynthetic demands of immune cells, also regulates a broad spectrum of cellular signal transduction, and influences immune cell survival, differentiation, and anti-tumor effector function. The cancer immunometabolism research field is rapidly evolving, and exciting new discoveries are reported in high-profile journals nearly weekly. Therefore, all new findings in this field cannot be summarized within this short review. Instead, this review is intended to provide a brief introduction to this rapidly developing research field, with a focus on the metabolism of two classes of important nutrients—lipids and amino acids—in immune cells. We highlight recent research on the roles of lipids and amino acids in regulating the metabolic fitness and immunological functions of T cells, macrophages, and natural killer cells in the tumor microenvironment. Furthermore, we discuss the possibility of "editing" metabolic pathways in immune cells to act synergistically with currently available immunotherapies in enhancing anti-tumor immune responses.
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作者姓名：
Jannis Wißfeld;Anke Werner;Xin Yan;Nora ten Bosch;Guoliang Cui
作者机构：
Helmholtz Institute for Translational Oncology(HI-TRON),Mainz 55131,Germany;T Cell Metabolism Group(D192 ,German Cancer Research Center(DKFZ),Heidelberg 69120,Germany;Faculty of Biosciences,Heidelberg University,Heidelberg 69120,Germany
文献出处：
引用格式：
[1]Jannis Wißfeld;Anke Werner;Xin Yan;Nora ten Bosch;Guoliang Cui-.Metabolic regulation of immune responses to cancer)[J].癌症生物学与医学（英文版）,2022(11):1528-1542
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0.573494
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