典型文献
Current Advances of Innate and Adaptive Immunity in Acute-on-Chronic Hepatitis B Liver Failure
文献摘要：
Acute-on-chronic hepatitis B liver failure (ACHBLF) is a term used to define the acute deterioration of liver function that occurs in patients with chronic hepatitis B virus infection or hepatitis B virus-related liver cirrhosis. The specific pathogenesis of ACHBLF is still not completely understood. Current research has shown that an intense systemic inflammation is involved in the development of acute-on-chronic liver failure (ACLF). Meanwhile, a subsequent immune paresis over the course of ACLF favors the development of infection and sepsis. Deregulation in both the innate and adaptive immunity is the notable feature of ACLF. The dysregulated immune responses play a crucial role in disease progression and potentially drive organ failure and mortality in ACHBLF. In this review, we highlight the current knowledge of innate and adaptive immune cells in ACHBLF.
文献关键词：
Acute-on-chronic liver failure;Adaptive immunity;Hepatitis B virus;Immune cells;Innate immunity
中图分类号：
作者姓名：
Wang Liyuan;Fan Yuchen
作者机构：
Department of Hepatology, Qilu Hospital of Shandong University, Jinan 250012, China;Department of Immunology, School of Basic Medical Science, Cheeloo College of Medicine, Shandong University, Jinan 250012, China
文献出处：
引用格式：
[1]Wang Liyuan;Fan Yuchen-.Current Advances of Innate and Adaptive Immunity in Acute-on-Chronic Hepatitis B Liver Failure)[J].感染性疾病和免疫（英文）,2022(02):113-121
A类：
ACHBLF,Deregulation
B类：
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AB值：
0.539058
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