典型文献
The Role of Macrophage-Derived Exosomes in Liver Diseases
文献摘要：
Exosomes (exos) widely distributed in a variety of biological fluids, including blood, urine, saliva, sputum, breast milk, cerebrospinal fluid, and ascites, contain specific bioactive contents which are involved in physiological and pathological processes, such as signal molecular transfer, substance metabolism, gene regulation, and immune regulation. Macrophages are important innate immune cells which usually act as the first line of defense against infection, and can switch between different functional phenotypes in response to the changes around the microenvironment. Evidence suggests that macrophage-derived exos exert a crucial effect on infection, inflammation, regeneration, tumors, fibrosis, and other lesions in multiple human diseases. However, the role and mechanism of macrophage-derived exos in liver diseases remain to be explored. This review summarizes the current researches on the role and possible mechanism of macrophage-derived exos in liver diseases, with the purpose of providing new potential targets and directions for diagnostic biomarker and clinical treatment of liver diseases.
文献关键词：
Exosomes;Liver disease;Macrophages
中图分类号：
作者姓名：
Lu Wang;Bai Li;Chen Yu
作者机构：
Fourth Department of Liver Disease (Difficult & Complicated Liver Diseases and Artificial Liver Center), Beijing Youan Hospital, Capital Medical University, Beijing 100069, China;Beijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research, Beijing 100069, China
文献出处：
引用格式：
[1]Lu Wang;Bai Li;Chen Yu-.The Role of Macrophage-Derived Exosomes in Liver Diseases)[J].感染性疾病和免疫（英文）,2022(01):34-41
A类：
B类：
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AB值：
0.669042
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