典型文献
Powassan virus: A tick borne flavivirus infecting humans
文献摘要：
Infection of humans by Powassan virus (POWV) occurs rarely but is potentially life-threatening. First isolated in Ontario, Canada in 1958, the presence of POWV has been confirmed in three countries: Canada, the USA, and Russia. Although a limited number of human cases has been reported thus far, the infection rate has shown signs of increasing during the 21
st century. Interestingly, POWV and a genetically close variant, deer tick virus (DTV), are the only member of the tick-borne flaviviruses known to be endemic in North America and maintain in respective tick-host cycles. In this review, we briefly summarize current knowledge involving the epidemiology and etiology, pathogenesis and immunity, molecular evolution, and protein functions of POWV, aiming to increase our understanding of the virus and unlock the potential to control this lethal pathogen. These data may also provide tools to minimize the future threat of other emerging and re-emerging viruses.
文献关键词：
Powassan virus (POWV);Deer tick virus (DTV);Tick-borne flavivirus (TBFV);Tick;Zoonotic disease;Encephalitis
中图分类号：
作者姓名：
Yang Xu;Gao George F.;Liu William J.
作者机构：
CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing 100101, China;State Key Laboratory of Natural and Biomimetic Drugs, Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China;NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, China
文献出处：
引用格式：
[1]Yang Xu;Gao George F.;Liu William J.-.Powassan virus: A tick borne flavivirus infecting humans)[J].生物安全与健康 （英文）,2022(01):30-37
A类：
Powassan,POWV,Tick,TBFV
B类：
tick,borne,infecting,humans,Infection,by,occurs,rarely,but,potentially,life,threatening,First,isolated,Ontario,Canada,presence,has,been,confirmed,three,countries,USA,Russia,Although,limited,number,cases,reported,thus,far,infection,rate,shown,signs,increasing,during,21
,century,Interestingly,genetically,close,variant,deer,DTV,only,member,flaviviruses,known,endemic,North,America,maintain,respective,host,cycles,this,review,we,briefly,summarize,current,knowledge,involving,epidemiology,etiology,pathogenesis,immunity,molecular,evolution,protein,functions,aiming,increase,our,understanding,unlock,control,lethal,These,data,may,also,provide,tools,minimize,future,other,emerging,Deer,Zoonotic,disease,Encephalitis
AB值：
0.572753
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
