By 26 August 2022, the number of cases of acute hepatitis of unknown etiology (AHUA) has drastically increased to 1115 distributed in 35 countries that fulfill the World Health Organization definition. Several hypotheses on the cause of AHUA have been proposed and are being investigated around the world. In the recent United Kingdom (UK) report, human adenovirus (HAdV) with adeno-associated virus (AAV) co-infection is the leading hypothesis. However, there is still limited evidence in establishing the causal relationship between AHUA and any potential aetiology. The leading aetiology continues to be HAdV infection. It is reported that HAdV genomics is not unusual among the population in the UK, especially among AUHA cases. Expanding the surveillance of HAdV and AAV in the population and the environment in the countries with AUHA cases is suggested to be the primary action. Metagenomics should be used in detecting other infectious pathogens on a larger scale, to supplement the detection of viruses in the blood, stool, and liver specimens from AUHA cases. It is useful to develop a consensus-specific case definition of AHUA to better understand the characteristics of these cases globally based on all the collected cases.

Acute hepatitis;Aetiology;Children;Disease surveillance

Wang Chao;Gao Zhi-Yong;Walsh Nick;Hadler Stephen;Lu Qing-Bin;Cui Fuqiang

Department of Laboratorial Science and Technology & Vaccine Research Center, School of Public Health, Peking University, No. 38 Xue-Yuan Road, Haidian District, Beijing 100191, People’s Republic of China;Global Center for Infectious Disease and Policy Research & Global Health and Infectious Diseases Group, Peking University, Beijing 100191, People’s Republic of China;Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control and Beijing Research Center for Preventive Medicine, Beijing, People’s Republic of China;Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Commerical Road, Melbourne 3000, Australia;Independent Consultant, Medical Epidemiology, Atlanta, GA, USA

贫困所致传染病（英文）

[1]Wang Chao;Gao Zhi-Yong;Walsh Nick;Hadler Stephen;Lu Qing-Bin;Cui Fuqiang-.Acute hepatitis of unknown aetiology among children around the world)[J].贫困所致传染病（英文）,2022(06):84-89

AHUA,AUHA,Metagenomics,Aetiology

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