Background::A One Health approach has been increasingly mainstreamed by the international community, as it provides for holistic thinking in recognizing the close links and inter-dependence of the health of humans, animals and the environment. However, the dearth of real-world evidence has hampered application of a One Health approach in shaping policies and practice. This study proposes the development of a potential evaluation tool for One Health performance, in order to contribute to the scientific measurement of One Health approach and the identification of gaps where One Health capacity building is most urgently needed.Methods::We describe five steps towards a global One Health index (GOHI), including (i) framework formulation; (ii) indicator selection; (iii) database building; (iv) weight determination; and (v) GOHI scores calculation. A cell-like framework for GOHI is proposed, which comprises an external drivers index (EDI), an intrinsic drivers index (IDI) and a core drivers index (CDI). We construct the indicator scheme for GOHI based on this framework after multiple rounds of panel discussions with our expert advisory committee. A fuzzy analytical hierarchy process is adopted to determine the weights for each of the indicators.Results::The weighted indicator scheme of GOHI comprises three first-level indicators, 13 second-level indicators, and 57 third-level indicators. According to the pilot analysis based on the data from more than 200 countries/territories the GOHI scores overall are far from ideal (the highest score of 65.0 out of a maximum score of 100), and we found considerable variations among different countries/territories (31.8-65.0). The results from the pilot analysis are consistent with the results from a literature review, which suggests that a GOHI as a potential tool for the assessment of One Health performance might be feasible.Conclusions::GOHI—subject to rigorous validation—would represent the world’s first evaluation tool that constructs the conceptual framework from a holistic perspective of One Health. Future application of GOHI might promote a common understanding of a strong One Health approach and provide reference for promoting effective measures to strengthen One Health capacity building. With further adaptations under various scenarios, GOHI, along with its technical protocols and databases, will be updated regularly to address current technical limitations, and capture new knowledge.

Antimicrobial resistance;Cell-like framework;Climate change;Food security;Global One Health index (GOHI);Global performance assessment;Governance;Zoonotic diseases

Zhang Xiao-Xi;Liu Jing-Shu;Han Le-Fei;Xia Shang;Li Shi-Zhu;Li Odel Y.;Kassegne Kokouvi;Li Min;Yin Kun;Hu Qin-Qin;Xiu Le-Shan;Zhu Yong-Zhang;Huang Liang-Yu;Wang Xiang-Cheng;Zhang Yi;Zhao Han-Qing;Yin Jing-Xian;Jiang Tian-Ge;Li Qin;Fei Si-Wei;Gu Si-Yu;Chen Fu-Min;Zhou Nan;Cheng Zi-Le;Xie Yi;Li Hui-Min;Chen Jin;Guo Zhao-Yu;Feng Jia-Xin;Ai Lin;Xue Jing-Bo;Ye Qian;Grant Liz;Song Jun-Xia;Simm Geoff;Utzinger Jürg;Guo Xiao-Kui;Zhou Xiao-Nong

School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China;One Health Center, Shanghai Jiao Tong University-The University of Edinburgh, Shanghai, People’s Republic of China;National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, Shanghai, People’s Republic of China;Shanghai Legislative Research Institute, Shanghai, People’s Republic of China;Zhuhai Branch, ESPRE, Beijing Normal University Zhuhai Campus, Zhuhai, Guangdong, People’s Republic of China;Global Health Academy, The University of Edinburgh, Edinburgh, UK;Food and Agriculture Organization of the United Nations, Rome, Italy;Global Academy of Agriculture and Food Systems, The University of Edinburgh, Edinburgh, UK;Swiss Tropical and Public Health Institute, Allschwil, Switzerland;University of Basel, Basel, Switzerland

贫困所致传染病（英文）

[1]Zhang Xiao-Xi;Liu Jing-Shu;Han Le-Fei;Xia Shang;Li Shi-Zhu;Li Odel Y.;Kassegne Kokouvi;Li Min;Yin Kun;Hu Qin-Qin;Xiu Le-Shan;Zhu Yong-Zhang;Huang Liang-Yu;Wang Xiang-Cheng;Zhang Yi;Zhao Han-Qing;Yin Jing-Xian;Jiang Tian-Ge;Li Qin;Fei Si-Wei;Gu Si-Yu;Chen Fu-Min;Zhou Nan;Cheng Zi-Le;Xie Yi;Li Hui-Min;Chen Jin;Guo Zhao-Yu;Feng Jia-Xin;Ai Lin;Xue Jing-Bo;Ye Qian;Grant Liz;Song Jun-Xia;Simm Geoff;Utzinger Jürg;Guo Xiao-Kui;Zhou Xiao-Nong-.Towards a global One Health index: a potential assessment tool for One Health performance)[J].贫困所致传染病（英文）,2022(03):12-26

mainstreamed,GOHI

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