Fecal microbiota transplantation (FMT) has been used as a core therapy for treating dysbiosis-related diseases by remodeling gut microbiota. The methodology and technology for improving FMT are stepping forward, mainly including washed microbiota transplantation (WMT), colonic transendoscopic enteral tubing (TET) for microbiota delivery, and purified Firmicutes spores from fecal matter. To improve the understanding of the clinical applications of FMT, we performed a systematic literature review on FMT published from 2011 to 2021. Here, we provided an overview of the reported clinical benefits of FMT, the methodology of processing FMT, the strategy of using FMT, and the regulations on FMT from a global perspective. A total of 782 studies were included for the final analysis. The present review profiled the effectiveness from all clinical FMT uses in 85 specific diseases as eight categories, including infections, gut diseases, microbiota–gut–liver axis, microbiota–gut–brain axis, metabolic diseases, oncology, hematological diseases, and other diseases. Although many further controlled trials will be needed, the dramatic increasing reports have shown the promising future of FMT for dysbiosis-related diseases in the gut or beyond the gut.

Fecal microbiota transplant;Washed microbiota transplantation;Transendoscopic enteral tube;Spore;Clostridioides difficile;Methodology;Microbiota–gut–brain axis

Wang Yun;Zhang Sheng;Borody Thomas J.;Zhang Faming

Medical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210011, China;Key Lab of Holistic Integrative Enterology, Nanjing Medical University, Nanjing, Jiangsu 210011, China;Center for Digestive Diseases, Sydney, NSW 2046, Australia;National Clinical Research Center for Digestive Diseases, Xi’an, Shaanxi 710032, China

中华医学杂志（英文版）

[1]Wang Yun;Zhang Sheng;Borody Thomas J.;Zhang Faming-.Encyclopedia of fecal microbiota transplantation: a review of effectiveness in the treatment of 85 diseases)[J].中华医学杂志（英文版）,2022(16):1927-1939

transendoscopic,Washed,Transendoscopic,Spore

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