典型文献
Recent advances in systemic lupus erythematosus and microbiota:from bench to bedside
文献摘要：
Systemic lupus erythematosus(SLE)is a complicated autoimmune disease affecting multiple systems and organs.It is highly heterogeneous,and it preferentially affects women at childbearing age,causing worldwide social burden.The pathogenesis of SLE mostly involves genetic predisposition,epigenetic dysregulation,overactivation of the immune system,and environment factors.Human microbiome,which is mostly composed of microbiota colonized in the gut,skin,and oral cavity,provides a natural microbiome barrier against environmental risks.The past decade of research has demonstrated a strong association between microbiota and metabolic diseases or gastrointestinal diseases.However,the role of microbiota in autoimmunity remains largely unknown until recently,when the technological and methodological progress facilitates further microbiota research in SLE.In this review,the latest research about the role and mechanisms of microbiota in SLE and the advances in the development of diagnostic and therapeutic strategies based on microbiota for SLE were summarized.
文献关键词：
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作者姓名：
Yijing Zhan;Qianmei Liu;Bo Zhang;Xin Huang;Qianjin Lu
作者机构：
Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases,Chinese Academy of Medical Sciences,Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs,Institute of Dermatology,Chinese Academy of Medical Sciences and Peking Union Medical College,Nanjing 210042,China;Department of Dermatology,The Second Xiangya Hospital of Central South University,Institute of Dermatology and Venereology of Central South University,Hunan Clinical Medicine Research Center for Major Skin Diseases and Skin Health,Changsha 410011,China
文献出处：
引用格式：
[1]Yijing Zhan;Qianmei Liu;Bo Zhang;Xin Huang;Qianjin Lu-.Recent advances in systemic lupus erythematosus and microbiota:from bench to bedside)[J].医学前沿,2022(05):686-700
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Recent,advances,systemic,lupus,erythematosus,microbiota,from,bench,bedside,Systemic,SLE,complicated,autoimmune,affecting,multiple,systems,organs,It,highly,heterogeneous,preferentially,affects,women,childbearing,age,causing,worldwide,social,burden,pathogenesis,mostly,involves,predisposition,epigenetic,dysregulation,overactivation,factors,Human,microbiome,which,composed,colonized,gut,skin,oral,cavity,provides,natural,barrier,against,environmental,risks,past,decade,research,has,demonstrated,strong,association,between,metabolic,diseases,gastrointestinal,However,role,autoimmunity,remains,largely,unknown,until,recently,when,technological,methodological,progress,facilitates,further,In,this,review,latest,about,mechanisms,development,diagnostic,therapeutic,strategies,were,summarized
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0.677417
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