典型文献
Association between intestinal microbiota and inflammatory bowel disease
文献摘要：
Inflammatory bowel disease (IBD), which includes Crohn' s disease (CD) and ulcera-tive colitis (UC), has emerged as a global disease with high incidence, long duration, devastating clinical symptoms, and low curability (relapsing immune response and barrier function defects). Mounting studies have been performed to investigate its pathogenesis to provide an ever- expanding arsenal of therapeutic options, while the precise etiology of IBD is not completely understood yet. Recent advances in high- throughput sequencing methods and animal models have provided new insights into the association between intestinal microbiota and IBD. In general, dysbiosis charac-terized by an imbalanced microbiota has been widely recognized as a pathology of IBD. However, intestinal microbiota alterations represent the cause or result of IBD process remains unclear. Therefore, more evidences are needed to identify the pre-cise role of intestinal microbiota in the pathogenesis of IBD. Herein, this review aims to outline the current knowledge of commonly used, chemically induced, and infec-tious mouse models, gut microbiota alteration and how it contributes to IBD, and dysregulated metabolite production links to IBD pathogenesis.
文献关键词：
中图分类号：
作者姓名：
Yunchang Zhang;Xuemeng Si;Ling Yang;Hui Wang;Ye Sun;Ning Liu
作者机构：
Ministry of Agriculture and Rural Affairs,Institute of Feed Research,Chinese Academy of Agricultural Sciences,Beijing,China;State Key Laboratory of Animal Nutrition,Department of Animal Nutrition and Feed Science,China Agricultural University,Beijing,China;Beijing Advanced Innovation Center for Food Nutrition and Human Health,Department of Nutrition and Health,China Agricultural University,Beijing,China;Department of Food and Bioengineering,Beijing Vocational College of Agriculture,Beijing,China;Institute of Medical Laboratory Animal Science,Chinese Academy of Medical Sciences&Comparative Medical Center,Peking Union Medical College,Beijing,China
文献出处：
引用格式：
[1]Yunchang Zhang;Xuemeng Si;Ling Yang;Hui Wang;Ye Sun;Ning Liu-.Association between intestinal microbiota and inflammatory bowel disease)[J].动物模型与实验医学（英文）,2022(04):311-322
A类：
ulcera,curability,tious
B类：
Association,between,intestinal,microbiota,inflammatory,bowel,disease,Inflammatory,IBD,which,includes,Crohn,CD,tive,colitis,UC,has,emerged,global,high,incidence,long,duration,devastating,clinical,symptoms,low,relapsing,immune,response,barrier,function,defects,Mounting,studies,have,been,performed,investigate,its,pathogenesis,expanding,arsenal,therapeutic,options,while,precise,etiology,not,completely,understood,yet,Recent,advances,throughput,sequencing,methods,animal,models,provided,new,insights,into,association,general,dysbiosis,charac,terized,by,imbalanced,widely,recognized,pathology,However,alterations,represent,cause,result,process,remains,unclear,Therefore,more,evidences,are,needed,identify,role,Herein,this,review,aims,outline,current,knowledge,commonly,used,chemically,induced,infec,mouse,gut,how,contributes,dysregulated,metabolite,production,links
AB值：
0.656762
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
