典型文献
FMO3-TMAO axis modulates the clinical outcome in chronic heart-failure patients with reduced ejection fraction:evidence from an Asian population
文献摘要：
The association among plasma trimethylamine-N-oxide(TMAO),FMO3 polymorphisms,and chronic heart failure(CHF)remains to be elucidated.TMAO is a microbiota-dependent metabolite from dietary choline and carnitine.A prospective study was performed including 955 consecutively diagnosed CHF patients with reduced ejection fraction,with the longest follow-up of 7 years.The concentrations of plasma TMAO and its precursors,namely,choline and carnitine,were determined by liquid chromatography-mass spectrometry,and the FMO3 E158K polymorphisms(rs2266782)were genotyped.The top tertile of plasma TMAO was associated with a significant increment in hazard ratio(HR)for the composite outcome of cardiovascular death or heart transplantation(HR=1.47,95％CI=1.13-1.91,P=0.004)compared with the lowest tertile.After adjustments of the potential confounders,higher TMAO could still be used to predict the risk of the primary endpoint(adjusted HR=1.33,95％CI=1.01-1.74,P=0.039).This result was also obtained after further adjustment for carnitine(adjusted HR=1.33,95％CI=1.01-1.74,P=0.039).The FMO3 rs2266782 polymorphism was associated with the plasma TMAO concentrations in our cohort,and lower TMAO levels were found in the AA-genotype.Thus,higher plasma TMAO levels indicated increased risk of the composite outcome of cardiovascular death or heart transplantation independent of potential confounders,and the FMO3 AA-genotype in rs2266782 was related to lower plasma TMAO levels.
文献关键词：
中图分类号：
作者姓名：
Haoran Wei;Mingming Zhao;Man Huang;Chenze Li;Jianing Gao;Ting Yu;Qi Zhang;Xiaoqing Shen;Liang Ji;Li Ni;Chunxia Zhao;Zeneng Wang;Erdan Dong;Lemin Zheng;Dao Wen Wang
作者机构：
Division of Cardiology,Department of Internal Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science&Technology and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders,Wuhan 430030,China;Department of Cardiology and Institute of Vascular Medicine,Peking University Third Hospital;NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides;Beijing Key Laboratory of Cardiovascular Receptors Research,Beijing 100191,China;The Institute of Cardiovascular Sciences,Peking University;Key Laboratory of Molecular Cardiovascular Science,Ministry of Education,Beijing 100191,China;Department of Cardiology,Zhongnan Hospital of Wuhan University,Wuhan 430071,China;Department of Cellular and Molecular Medicine,Lerner Research Institute,Cleveland Clinic,Cleveland,OH 44195,USA
文献出处：
引用格式：
[1]Haoran Wei;Mingming Zhao;Man Huang;Chenze Li;Jianing Gao;Ting Yu;Qi Zhang;Xiaoqing Shen;Liang Ji;Li Ni;Chunxia Zhao;Zeneng Wang;Erdan Dong;Lemin Zheng;Dao Wen Wang-.FMO3-TMAO axis modulates the clinical outcome in chronic heart-failure patients with reduced ejection fraction:evidence from an Asian population)[J].医学前沿,2022(02):295-305
A类：
FMO3,E158K,rs2266782
B类：
TMAO,axis,modulates,clinical,outcome,chronic,heart,failure,patients,reduced,ejection,fraction,evidence,from,Asian,population,association,among,plasma,trimethylamine,oxide,polymorphisms,CHF,remains,be,elucidated,microbiota,metabolite,dietary,choline,carnitine,prospective,study,was,performed,including,consecutively,diagnosed,longest,follow,up,years,concentrations,its,precursors,namely,were,determined,by,liquid,chromatography,mass,spectrometry,genotyped,top,tertile,associated,significant,increment,hazard,composite,cardiovascular,death,transplantation,compared,lowest,After,adjustments,potential,confounders,higher,could,still,used,predict,risk,primary,endpoint,adjusted,This,result,also,obtained,after,further,our,cohort,lower,levels,AA,Thus,indicated,increased,independent,related
AB值：
0.4645
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
