典型文献
Role of gut microbiota in primary biliary cholangitis
文献摘要：
Primary biliary cholangitis(PBC,formerly known as primary biliary cirrhosis)is a chronic female-predominant inflammatory and cholestatic liver disease with a prolonged course and poor prognosis[1].It is characterized by anti-mitochondrial autoanti-body(AMA),immunoglobulin M and lymphocyte infiltration in the portal area of liver tissue.A recent systemic review has shown a steady rise both in incidence and prevalence of PBC,with 5.31/100 000 persons and 40.2/100 000 persons,respectively[2].It can cause fatigue,pruritus and is associated with a high risk of cirrhosis and liver failure if left untreated[3].The pathogenesis of PBC may be related to genetic,environmental,immune factors and individual susceptibility,but the specific etiology is not clear.Several previous studies[4,5]have found that gut microbiota plays an important role in a variety of liver diseases,including PBC.The bidirectional crosstalk between liver and microbiome appears to be crucial in maintaining health and could be therapeutically targeted,such as by fecal microbiota transplantation.
文献关键词：
中图分类号：
作者姓名：
Wu-Meng Jin;Si-Yue Song;Xiao-Fen Xu;Cheng-Ping Wen;Chang-Feng Hu
作者机构：
College of Basic Medical Sciences,Zhejiang Chinese Medical University,Hangzhou 310053,China
文献出处：
引用格式：
[1]Wu-Meng Jin;Si-Yue Song;Xiao-Fen Xu;Cheng-Ping Wen;Chang-Feng Hu-.Role of gut microbiota in primary biliary cholangitis)[J].国际肝胆胰疾病杂志(英文版),2022(06):597-599
A类：
autoanti
B类：
Role,gut,microbiota,primary,biliary,cholangitis,Primary,PBC,formerly,known,cirrhosis,chronic,female,predominant,inflammatory,cholestatic,liver,prolonged,course,poor,prognosis,It,characterized,by,mitochondrial,body,AMA,immunoglobulin,lymphocyte,infiltration,portal,area,tissue,recent,systemic,review,has,shown,steady,rise,both,incidence,prevalence,persons,respectively,can,cause,fatigue,pruritus,associated,high,risk,failure,left,untreated,pathogenesis,may,related,genetic,environmental,immune,factors,individual,susceptibility,but,specific,etiology,not,clear,Several,previous,studies,have,found,that,plays,important,role,variety,diseases,including,bidirectional,crosstalk,between,microbiome,appears,crucial,maintaining,health,could,therapeutically,targeted,such,fecal,transplantation
AB值：
0.684588
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