典型文献
Helicobacter pylori may participate in the development of inflammatory bowel disease by modulating the intestinal microbiota
文献摘要：
Inflammatory bowel disease (IBD) is a non-specific inflammatory disease of the gastrointestinal (GI) tract that is generally accepted to be closely related to intestinal dysbiosis in the host. GI infections contribute a key role in the pathogenesis of IBD; however, although the results of recent clinical studies have revealed an inverse correlation between Helicobacter pylori (
H. pylori) infection and IBD, the exact mechanism underlying the development of IBD remains unclear.
H. pylori, as a star microorganism, has been a focus for decades, and recent preclinical and real-world studies have demonstrated that
H. pylori not only affects the changes in the gastric microbiota and microenvironment but also influences the intestinal microbiota, indicating a potential correlation with IBD. Detailed analysis revealed that
H. pylori infection increased the diversity of the intestinal microbiota, reduced the abundance of Bacteroidetes, augmented the abundance of
Firmicutes, and produced short-chain fatty acid-producing bacteria such as
Akkermansia. All these factors may decrease vulnerability to IBD. Further studies investigating the
H. pylori-intestinal microbiota metabolite axis should be performed to understand the mechanism underlying the development of IBD.
文献关键词：
Helicobacter pylori;Inflammatory bowel disease;Intestinal microbiota
中图分类号：
作者姓名：
Bai Xiaoyin;Jiang Lingjuan;Ruan Gechong;Liu Tingting;Yang Hong
作者机构：
Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China;Department of Medical Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
文献出处：
引用格式：
[1]Bai Xiaoyin;Jiang Lingjuan;Ruan Gechong;Liu Tingting;Yang Hong-.Helicobacter pylori may participate in the development of inflammatory bowel disease by modulating the intestinal microbiota
)[J].中华医学杂志（英文版）,2022(06):634-638
A类：
microbiota
B类：
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AB值：
0.544448
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
