典型文献
Emerging role of protein modification in inflammatory bowel disease
文献摘要：
The onset of inflammatory bowel disease (IBD) involves many factors, including environmental parameters, microor-ganisms, and the immune system. Although research on IBD continues to expand, the specific pathogenesis mechanism is still unclear. Protein modification refers to chemical modification after protein biosynthesis, also known as post-translational modifi-cation (PTM), which causes changes in the properties and functions of proteins. Since proteins can be modified in different ways, such as acetylation, methylation, and phosphorylation, the functions of proteins in different modified states will also be different. Transitions between different states of protein or changes in modification sites can regulate protein properties and functions. Such modifications like neddylation, sumoylation, glycosylation, and acetylation can activate or inhibit various signaling pathways (e.g., nuclear factor-κB (NF-κB), extracellular signal-regulated kinase (ERK), and protein kinase B (AKT)) by changing the intestinal flora, regulating immune cells, modulating the release of cytokines such as interleukin-1β(IL-1β), tumor necrosis factor-α(TNF-α), and interferon-γ(IFN-γ), and ultimately leading to the maintenance of the stability of the intes-tinal epithelial barrier. In this review, we focus on the current understanding of PTM and describe its regulatory role in the patho-genesis of IBD.
文献关键词：
中图分类号：
作者姓名：
Gaoying WANG;Jintao YUAN;Ji LUO;Dickson Kofi Wiredu OCANSEY;Xu ZHANG;Hui QIAN;Wenrong XU;Fei MAO
作者机构：
Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province,School of Medicine,Jiangsu University,Zhenjiang 212013,China;Clinical Laboratory,Wuxi Maternal and Child Health Hospital Affiliated to Nanjing Medical University,Wuxi 214002,China;Clinical Laboratory,the People's Hospital of Danyang,Affiliated Danyang Hospital of Nantong University,Zhenjiang 212300,China;Directorate of University Health Services,University of Cape Coast,Cape Coast 02630,Ghana
引用格式：
[1]Gaoying WANG;Jintao YUAN;Ji LUO;Dickson Kofi Wiredu OCANSEY;Xu ZHANG;Hui QIAN;Wenrong XU;Fei MAO-.Emerging role of protein modification in inflammatory bowel disease)[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2022(03):173-188
A类：
microor,sumoylation
B类：
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AB值：
0.565688
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